| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cholecystokinin receptor type A, CCK-A receptor, CCK-AR, Cholecystokinin-1 receptor, CCK1-R, CCKAR, CCKRA |
| Entrez GeneID | 886 |
| WB Predicted band size | 47.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CCKAR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228-257 amino acids from the Central region of human CCKAR. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CCKAR(胆囊收缩素A受体)抗体的模拟参考文献示例。请注意，这些文献信息为虚构，仅供参考格式和内容方向，实际文献需通过学术数据库查询：
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1. **文献名称**: *"Expression and Functional Characterization of CCKAR Antibodies in Pancreatic Cancer Models"*
**作者**: Smith J, et al.
**摘要**: 本研究利用特异性CCKAR抗体检测了胰腺癌细胞系及组织中受体的表达水平，发现CCKAR的高表达与肿瘤侵袭性和患者不良预后相关。通过抗体阻断实验，证实CCKAR信号通路促进癌细胞增殖和迁移。
2. **文献名称**: *"Development of a Novel Monoclonal Antibody for Cholecystokinin Receptor A (CCKAR) and Its Application in Gastrointestinal Studies"*
**作者**: Lee H, et al.
**摘要**: 研究团队开发了一种高特异性抗CCKAR单克隆抗体，并通过免疫组化和流式细胞术验证其在胃肠道组织中的结合能力。该抗体成功用于探究CCKAR在调节消化酶分泌及饱腹感中的作用机制。
3. **文献名称**: *"CCKAR Antibody-Based Imaging Probes for Obesity-Related Metabolic Disorders"*
**作者**: Garcia R, et al.
**摘要**: 本文报道了一种基于CCKAR抗体的分子影像探针，用于活体检测肥胖模型中受体表达的变化。结果显示，CCKAR在脂肪组织中的异常表达可能与胰岛素抵抗相关，提示其作为代谢疾病治疗靶点的潜力。
4. **文献名称**: *"Role of CCKAR in Chronic Pancreatitis: Insights from Antibody-Mediated Receptor Inhibition"*
**作者**: Wang Y, et al.
**摘要**: 通过抗CCKAR抗体抑制受体活性，研究慢性胰腺炎模型中胆囊收缩素信号的影响。实验表明，CCKAR的过度激活加剧炎症反应，而抗体干预可显著缓解组织损伤。
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**建议**：如需真实文献，请访问 **PubMed**(https://pubmed.ncbi.nlm.nih.gov)或 **Google Scholar**，搜索关键词如“CCKAR antibody”、“Cholecystokinin receptor A antibody”+“应用方向(如癌症、代谢疾病等)”。
The cholecystokinin A receptor (CCKAR), also known as CCK1R, is a G protein-coupled receptor (GPCR) primarily expressed in the gastrointestinal tract, pancreas, and central nervous system. It binds cholecystokinin (CCK), a peptide hormone involved in digestion, appetite regulation, and anxiety modulation. CCKAR activation triggers intracellular signaling pathways, including phospholipase C and MAP kinase, influencing processes like enzyme secretion, gut motility, and satiety. Dysregulation of CCKAR is linked to metabolic disorders, pancreatitis, and certain cancers.
CCKAR(Center) antibodies are immunological tools developed to target specific epitopes of the receptor, often used in research to study its expression, localization, and function. These antibodies are typically validated for applications such as Western blotting, immunohistochemistry, and immunofluorescence. Monoclonal CCKAR antibodies offer high specificity, while polyclonal versions may detect broader epitopes. Their development has advanced studies on receptor-ligand interactions, cellular signaling, and therapeutic targeting for conditions like obesity or gastrointestinal cancers. Proper validation remains critical due to potential cross-reactivity with homologous receptors like CCKBR (CCK2R).
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