| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Calpain small subunit 2, CSS2, Calcium-dependent protease small subunit 2, CAPNS2 |
| Entrez GeneID | 84290 |
| WB Predicted band size | 27.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This CAPNS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the Central region of human CAPNS2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CAPNS2抗体的3篇文献示例(注：文献信息为模拟概括，实际引用需查询具体数据库)：
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1. **文献名称**：*"Calpain Small Subunit 2 (CAPNS2) Promotes Tumor Angiogenesis in Glioblastoma via VEGF Signaling"*
**作者**：Zhang Y, et al.
**摘要**：该研究通过免疫组化(使用CAPNS2抗体)发现，CAPNS2在胶质母细胞瘤中高表达，并通过调控VEGF通路促进肿瘤血管生成，提示其作为治疗靶点的潜力。
2. **文献名称**：*"Functional Analysis of CAPNS2 in Neuronal Differentiation Using CRISPR/Cas9 Knockout Models"*
**作者**：Li H, et al.
**摘要**：通过构建CAPNS2基因敲除细胞模型，结合Western Blot(使用CAPNS2抗体验证蛋白缺失)，研究发现CAPNS2缺失会抑制神经元分化，提示其在神经发育中的关键作用。
3. **文献名称**：*"CAPNS2 as a Novel Biomarker for Early-Stage Lung Adenocarcinoma"*
**作者**：Wang X, et al.
**摘要**：利用CAPNS2抗体对临床肺癌组织进行检测，发现其表达水平与患者预后显著相关，且可通过血清外泌体CAPNS2含量实现无创早期诊断。
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**说明**：以上内容为示例性概括，真实文献需通过PubMed、Web of Science等平台检索。CAPNS2抗体相关研究多集中于其调控钙蛋白酶活性、疾病机制(如癌症、神经退行性疾病)及作为诊断工具的应用。
The CAPNS2 antibody targets the calpain small subunit 2 (CAPNS2), a regulatory component of the calcium-dependent cysteine protease system, calpain. Calpains are heterodimeric enzymes composed of a large catalytic subunit (e.g., CAPN1. CAPN2) and a small regulatory subunit (CAPNS1 or CAPNS2). While CAPNS1 is ubiquitously expressed and essential for stabilizing the catalytic subunits, CAPNS2 exhibits tissue-specific expression, predominantly in placental, muscle, and certain cancer cells. CAPNS2 is thought to regulate calpain activity in specific physiological or pathological contexts, such as myogenesis, cell migration, and tumor progression.
Studies suggest CAPNS2 may compensate for CAPNS1 in some tissues or modulate calpain isoform specificity. Its overexpression has been linked to cancer metastasis, invasion, and poor prognosis, particularly in breast cancer and glioblastoma. The CAPNS2 antibody is a critical tool for detecting CAPNS2 protein levels via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers use it to explore CAPNS2's role in calpain-mediated signaling pathways, cellular processes, and disease mechanisms, aiding the development of targeted therapies. The antibody’s specificity helps distinguish CAPNS2 from CAPNS1. enabling precise investigation of its unique functions in health and disease.
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