| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Band 41-like protein 5, EPB41L5, KIAA1548 |
| Entrez GeneID | 57669 |
| WB Predicted band size | 81.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This EPB41L5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 355-383 amino acids from the Central region of human EPB41L5. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于EPB41L5抗体的参考文献示例(注：以下内容为模拟构造，实际文献需通过学术数据库验证)：
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1. **文献名称**: *EPB41L5 modulates Wnt/β-catenin signaling to suppress colorectal cancer metastasis*
**作者**: Tanaka K, et al.
**摘要**: 本研究通过免疫组化(EPB41L5抗体)发现，EPB41L5在结直肠癌低表达与患者预后不良相关。体外实验表明，EPB41L5通过抑制β-catenin核转位阻断Wnt信号通路，降低癌细胞侵袭能力，提示其作为转移抑制因子的潜在机制。
2. **文献名称**: *EPB41L5 maintains epithelial polarity by regulating tight junction dynamics*
**作者**: Smith J, et al.
**摘要**: 利用EPB41L5抗体进行免疫荧光染色，揭示EPB41L5通过与Par3/aPKC复合体互作维持上皮细胞极性。基因敲除导致紧密连接破坏并促进EMT，提示其在组织屏障功能及癌症早期转移中的关键作用。
3. **文献名称**: *Developmental expression of EPB41L5 in zebrafish embryogenesis*
**作者**: Chen L, et al.
**摘要**: 通过斑马鱼模型结合EPB41L5抗体的Western blot分析，发现EPB41L5在神经嵴细胞迁移中高表达，干扰其功能导致胚胎形态发育缺陷，表明其对细胞骨架重塑和胚胎极性的调控意义。
4. **文献名称**: *EPB41L5 as a biomarker for triple-negative breast cancer progression*
**作者**: Gupta R, et al.
**摘要**: 基于EPB41L5抗体的组织芯片分析显示，EPB41L5在三阴性乳腺癌中显著下调，且与淋巴结转移呈负相关。机制研究提示其通过抑制RhoA/ROCK通路调控细胞迁移，或成为预后评估的新靶点。
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**注意事项**：
- 上述文献为示例性内容，实际引用需检索PubMed、Web of Science等平台获取真实数据。
- 研究EPB41L5时建议关注其在细胞粘附、EMT、癌症转移及发育生物学中的功能，并注意抗体特异性验证信息(如品牌、货号)。
The EPB41L5 antibody targets the Erythrocyte Membrane Protein Band 4.1 Like 5 (EPB41L5), a member of the 4.1 superfamily of cytoskeletal proteins. EPB41L5. also known as PALS4 or FRMD6. is a scaffolding protein involved in cell adhesion, polarity, and membrane-cytoskeleton organization. It contains a conserved FERM (4.1-ezrin-radixin-moesin) domain, enabling interactions with transmembrane proteins and cytoskeletal components. EPB41L5 plays critical roles in epithelial-mesenchymal transition (EMT), tissue morphogenesis, and cell migration by regulating adherens junctions and focal adhesions. Its dysregulation has been linked to cancer progression and metastasis.
The EPB41L5 antibody is widely used in research to study cell polarity dynamics, tumor invasiveness, and developmental biology. It enables detection of EPB41L5 expression in various models (cell lines, tissues, animal models) via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Commercially available as monoclonal or polyclonal versions (rabbit, mouse), this antibody helps elucidate EPB41L5's molecular mechanisms in maintaining epithelial integrity and its crosstalk with signaling pathways like Hippo and Wnt. Recent studies highlight its potential as a biomarker in cancers, particularly in evaluating EMT-related therapeutic targets.
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