| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein ZNF783, ZNF783 |
| Entrez GeneID | 100289678 |
| WB Predicted band size | 31.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZNF783 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ZNF783. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZNF783 (N-term)抗体的假设性参考文献示例(注：由于实际文献可能有限，以下内容基于典型研究场景构建，建议通过学术数据库核实具体文献)：
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1. **文献名称**：*Characterization of ZNF783 as a Novel Transcriptional Regulator in Cancer*
**作者**：Smith J, et al. (2020)
**摘要**：本研究利用针对ZNF783 N端结构域的多克隆抗体，通过染色质免疫沉淀(ChIP)和Western blot分析，揭示了ZNF783在乳腺癌中调控致癌基因表达的机制。抗体特异性通过siRNA敲低实验验证。
2. **文献名称**：*Development of Monoclonal Antibodies Targeting Zinc Finger Proteins for Epigenetic Studies*
**作者**：Zhang Y, et al. (2018)
**摘要**：报道了一种针对ZNF783 N端表位的单克隆抗体的开发，该抗体在免疫组化(IHC)和免疫荧光(IF)中表现出高特异性，用于研究ZNF783在细胞核内的定位及其与染色质修饰复合物的相互作用。
3. **文献名称**：*ZNF783 Knockout Mice Reveal Roles in Neural Development*
**作者**：Lee H, et al. (2019)
**摘要**：通过使用ZNF783 N端抗体进行组织特异性Western blot和免疫沉淀，研究发现ZNF803在小鼠大脑发育中调控神经元分化，抗体验证了基因敲除模型中蛋白表达的缺失。
4. **文献名称**：*Comparative Analysis of Zinc Finger Protein Antibodies in Genome-wide Binding Studies*
**作者**：Brown K, et al. (2021)
**摘要**：系统性评估了多种锌指蛋白抗体(包括ZNF783 N-term抗体)在ChIP-seq中的性能，确认其适用于全基因组DNA结合位点分析，并提供了交叉验证数据。
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**备注**：若实际文献不足，建议：
1. 检索PubMed、Google Scholar等平台，关键词：`ZNF783 antibody N-terminal` + `epitope`/`validation`;
2. 查阅抗体供应商(如Abcam、Sigma)的产品说明书，部分会引用相关文献;
3. 关注ZNF蛋白家族或表观遗传调控相关综述，可能提及ZNF783抗体的应用场景。
The ZNF783 (N-term) antibody is designed to target the N-terminal region of the zinc finger protein 783 (ZNF783), also known as JHAZ or ZKSCAN5. ZNF783 belongs to the Krüppel-associated box (KRAB) domain-containing zinc finger protein family, characterized by C2H2-type zinc finger motifs that facilitate DNA binding and protein interactions. These proteins often function as transcriptional regulators, influencing chromatin remodeling and gene expression. ZNF783 is implicated in various cellular processes, including differentiation, apoptosis, and tumorigenesis. Its role in cancer is of particular interest, with studies suggesting involvement in pathways linked to tumor suppression or oncogenesis depending on cellular context.
The N-terminal region of ZNF783 contains the KRAB domain, which typically mediates interactions with co-repressors to recruit chromatin-modifying complexes, thereby silencing target genes. Antibodies targeting this region are valuable tools for studying ZNF783's expression, localization, and molecular interactions. They are commonly used in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to investigate its regulatory mechanisms. Validation of ZNF783 (N-term) antibodies often includes specificity tests using knockout cell lines or siRNA-mediated knockdown to confirm signal reduction. Researchers utilize these antibodies to explore ZNF783's potential as a biomarker or therapeutic target in diseases such as cancer, neurological disorders, or developmental conditions linked to zinc finger protein dysregulation.
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