| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein 737, Zinc finger protein 102, ZNF737, ZNF102 |
| Entrez GeneID | 100129842 |
| WB Predicted band size | 61.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZNF737 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-112 amino acids from the N-terminal region of human ZNF737. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZNF737 (N-term)抗体的参考文献示例(注：以下内容为模拟生成，实际文献需通过学术数据库验证)：
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1. **文献名称**：*ZNF737 Expression in Hepatocellular Carcinoma: Prognostic Implications*
**作者**：Zhang S, et al.
**摘要**：研究通过ZNF737 (N-term)抗体进行免疫组化分析，发现ZNF737在肝癌组织中表达下调，且低表达与患者生存率降低显著相关，提示其潜在肿瘤抑制功能。
2. **文献名称**：*Functional Characterization of ZNF737 in Neuronal Differentiation*
**作者**：Li M, et al.
**摘要**：利用ZNF737 (N-term)抗体进行Western blot和免疫荧光实验，证实ZNF737在小鼠神经元分化过程中高表达，并参与调控神经标志物基因的转录激活。
3. **文献名称**：*Genome-wide CRISPR Screen Identifies ZNF737 as a Modulator of DNA Repair*
**作者**：Wang X, et al.
**摘要**：通过ZNF737 (N-term)抗体进行染色质免疫沉淀(ChIP)，发现ZNF737与DNA损伤修复通路相关基因的启动子区域结合，可能参与维持基因组稳定性。
4. **文献名称**：*ZNF737 Polymorphisms and Autoimmune Disease Susceptibility*
**作者**：Chen L, et al.
**摘要**：采用ZNF737 (N-term)抗体检测患者外周血单核细胞中的蛋白水平，结合基因分型分析，揭示特定ZNF737 SNP与系统性红斑狼疮的遗传关联及表达调控机制。
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**注意**：以上文献为示例，实际研究中ZNF737相关抗体文献可能有限，建议通过PubMed、Web of Science等平台结合关键词“ZNF737 antibody”、“N-terminal”和“immunolocalization”进一步检索。部分商业抗体公司(如Abcam、Sigma-Aldrich)的产品说明页也可能提供引用文献。
The ZNF737 (N-term) antibody is designed to target the N-terminal region of zinc finger protein 737 (ZNF737), a member of the Krüppel-associated box (KRAB)-containing zinc finger protein (ZFP) family. These proteins are characterized by tandem C₂H₂ zinc finger motifs, which mediate sequence-specific DNA binding, and a KRAB domain, often involved in transcriptional repression via interaction with co-repressors. ZNF737 is hypothesized to function as a transcription factor, regulating gene expression in processes such as cell differentiation, proliferation, and apoptosis. Dysregulation of ZNF proteins has been implicated in cancers and developmental disorders.
The N-terminal-specific antibody enables the detection of ZNF737 in applications like Western blotting, immunofluorescence, or chromatin immunoprecipitation (ChIP), helping researchers study its expression, localization, and molecular interactions. While the full biological role of ZNF737 remains under investigation, its structural similarity to other KRAB-ZFPs suggests potential involvement in epigenetic silencing or transposable element regulation. Studies have linked altered ZNF737 expression to diseases, including prostate and gastric cancers, highlighting its possible utility as a biomarker or therapeutic target. Commercial ZNF737 (N-term) antibodies are typically validated for specificity in human or model organisms, aiding mechanistic studies in cancer biology, developmental research, and gene regulation networks.
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