| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein 736, ZNF736 |
| Entrez GeneID | 728927 |
| WB Predicted band size | 49.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZNF736 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-75 amino acids from the N-terminal region of human ZNF736. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZNF736(N-term)抗体的3篇参考文献的示例(注：以下内容为模拟示例，实际文献可能需要通过学术数据库检索确认)：
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1. **文献名称**: *"Characterization of ZNF736 as a novel transcriptional repressor in cancer cell lines"*
**作者**: Smith A, et al. (2020)
**摘要**: 本研究利用ZNF736(N-term)特异性抗体(货号：AB123)，通过Western blot和免疫荧光技术，验证了ZNF736在多种癌细胞系中的核定位。研究发现ZNF736通过其N端结构域与染色质结合，抑制下游肿瘤抑制基因的表达，提示其在癌症中的潜在作用。
2. **文献名称**: *"Genome-wide analysis of ZNF736 binding sites reveals its role in epigenetic regulation"*
**作者**: Chen L, et al. (2018)
**摘要**: 通过ChIP-seq技术结合ZNF736(N-term)抗体(供应商：XYZ Biotech)，作者鉴定了ZNF736在全基因组范围内的靶向结合位点，发现其富集于启动子区域的CpG岛，并参与DNA甲基化调控，为ZNF736在表观遗传中的作用提供了证据。
3. **文献名称**: *"Developmental expression and functional screening of zinc finger protein ZNF736 in zebrafish"*
**作者**: Wang Y, et al. (2019)
**摘要**: 研究利用ZNF736(N-term)多克隆抗体进行斑马鱼胚胎的免疫组化分析，揭示了该蛋白在神经系统发育中的时空特异性表达。通过基因敲降实验，发现ZNF736缺失导致神经管发育异常，表明其在中胚层分化中的关键功能。
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**注意**：以上文献信息为模拟生成，实际引用时需通过PubMed、Google Scholar等平台检索真实文献(关键词：ZNF736 antibody、N-terminal epitope)。若研究较少，可扩展至ZNF家族蛋白或相关通路的研究。
The ZNF736 (N-term) antibody is a research tool designed to detect the N-terminal region of zinc finger protein 736 (ZNF736), a member of the Krüppel-associated box (KRAB)-containing zinc finger protein (ZNF) family. ZNF proteins are characterized by tandem C2H2-type zinc finger domains, which facilitate sequence-specific DNA binding, and KRAB domains, often involved in transcriptional repression via interaction with co-repressors. ZNF736 is hypothesized to function in gene regulation, particularly in developmental processes or cellular differentiation, though its precise biological roles remain under investigation.
The N-terminal region of ZNF736 may contain regulatory or protein-interaction motifs critical for its function. Antibodies targeting this region are commonly used in techniques like Western blotting, immunofluorescence, or chromatin immunoprecipitation (ChIP) to study ZNF736 expression, localization, and DNA-binding activity. Validation typically includes testing on knockout cell lines or tissues to confirm specificity.
Research involving ZNF736 may explore its potential links to diseases, such as cancer or neurological disorders, given the association of other ZNF proteins with these conditions. The ZNF736 (N-term) antibody thus serves as a key reagent for elucidating the protein’s molecular mechanisms and contributions to cellular pathways. Commercial sources often provide species reactivity (e.g., human, mouse) and recommended applications, but users should optimize experimental conditions for their specific models.
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