| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cell surface glycoprotein CD200 receptor 2, CD200 cell surface glycoprotein receptor-like 2, CD200 receptor-like 2, HuCD200R2, CD200 cell surface glycoprotein receptor-like a, CD200RLa, Cell surface glycoprotein CD200 receptor 1-like, Cell surface glycoprotein OX2 receptor 2, CD200R1L, CD200R2 |
| Entrez GeneID | 344807 |
| WB Predicted band size | 29.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CD200R1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-92 amino acids from the N-terminal region of human CD200R1L. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CD200R1L (N-term)抗体的模拟参考文献示例(基于假设性研究内容，实际文献需通过学术数据库查询)：
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1. **文献名称**：*"HCMV UL141 Targets CD200R1L to Evade NK Cell Surveillance"*
**作者**：Smith A, et al.
**摘要**：研究揭示了人巨细胞病毒(HCMV)蛋白UL141通过结合CD200R1L抑制NK细胞的杀伤功能，实验中采用CD200R1L (N-term)抗体阻断该互作，恢复NK细胞活性，为抗病毒免疫逃逸机制提供新见解。
2. **文献名称**：*"CD200R1L as an Immune Checkpoint in Tumor Microenvironments"*
**作者**：Jones B, et al.
**摘要**：本文发现CD200R1L在黑色素瘤中高表达，并通过N端结构域与免疫细胞相互作用。使用CD200R1L (N-term)抗体阻断信号通路，可增强T细胞抗肿瘤反应，提示其作为潜在免疫治疗靶点。
3. **文献名称**：*"Development of a Monoclonal Antibody Against CD200R1L N-terminal Domain"*
**作者**：Brown C, et al.
**摘要**：报道了一种针对CD200R1L N端的单克隆抗体的开发与验证，通过ELISA、流式细胞术和免疫组化证实其高特异性，为后续功能研究和疾病模型应用奠定基础。
4. **文献名称**：*"CD200R1L Modulates Microglial Activation in Neuroinflammation"*
**作者**：Lee D, et al.
**摘要**：研究利用CD200R1L (N-term)抗体，发现其在小胶质细胞中阻断CD200R1L信号可减轻实验性自身免疫性脑脊髓炎(EAE)模型的神经炎症，提示其在神经退行性疾病中的调控作用。
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**说明**：以上为模拟示例，实际文献需通过PubMed、Google Scholar等平台以关键词“CD200R1L antibody”“CD200R1L function”等检索获取。
The CD200R1L (N-term) antibody is a targeted reagent used to detect the N-terminal region of the CD200 receptor-like protein 1 (CD200R1L), a member of the CD200 receptor family. CD200R1L, also known as CD200 receptor-like protein 1. is a cell surface glycoprotein belonging to the immunoglobulin superfamily (IgSF). It shares structural homology with CD200R, a receptor for CD200. an immunoregulatory ligand involved in modulating immune responses, particularly in maintaining immune tolerance and suppressing excessive inflammation. CD200R1L is thought to interact with CD200 or related ligands, though its precise binding partners and signaling mechanisms remain under investigation.
This antibody is commonly utilized in research applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study CD200R1L expression patterns in tissues or cell lines. The N-terminal region targeted by the antibody is critical for ligand-receptor interactions, making it a valuable tool for exploring the protein’s functional roles. CD200R1L is implicated in immune checkpoint regulation, with potential relevance to cancer immunotherapy, autoimmune diseases, and neuroinflammatory conditions. Studies suggest its expression on immune cells, including macrophages and dendritic cells, where it may fine-tune inflammatory responses. Validation of this antibody typically includes knockout controls to confirm specificity. Its development aligns with growing interest in immune checkpoint pathways and therapeutic targeting.
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