| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Leucine-rich repeat-containing protein 69, LRRC69 |
| Entrez GeneID | 100130742 |
| WB Predicted band size | 39.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This LRRC69 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-227 amino acids from the Central region of human LRRC69. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于LRRC69抗体的部分参考文献(注：LRRC69研究较新，相关文献有限，以下为模拟示例)：
1. **"LRRC69 regulates immune cell function via TLR signaling pathways"**
- 作者：Zhang Y, et al.
- 摘要：本研究通过构建LRRC69基因敲除小鼠模型，利用LRRC69特异性抗体进行免疫组化和Western blot分析，发现LRRC69通过调控TLR4信号通路影响巨噬细胞的炎症反应。
2. **"Identification of LRRC69 as a tumor suppressor in lung adenocarcinoma"**
- 作者：Wang L, et al.
- 摘要：通过免疫荧光(使用抗LRRC69抗体)和RNA-seq技术，发现LRRC69在肺癌组织中低表达，其缺失促进肿瘤细胞增殖，提示其可能通过调控细胞周期蛋白发挥作用。
3. **"Proteomic analysis of LRRC69 interactions in spermatogenesis"**
- 作者：Chen H, et al.
- 摘要：利用抗LRRC69抗体进行Co-IP实验，鉴定了LRRC69在精子发生过程中与多个减数分裂相关蛋白的相互作用，揭示其在生殖细胞发育中的潜在功能。
**备注**：LRRC69研究尚处早期，实际文献可能较少，建议通过PubMed或Google Scholar以“LRRC69 antibody”为关键词检索最新成果，或关注相关基因家族(如LRRC蛋白)的功能研究。
LRRC69 (Leucine-Rich Repeat-Containing Protein 69) is a relatively understudied protein belonging to the leucine-rich repeat (LRR) superfamily, characterized by tandem repeats of 20-30 amino acid motifs rich in leucine residues. These proteins are often involved in protein-protein interactions, cellular signaling, and immune responses. LRRC69 is encoded by the *LRRC69* gene, located on human chromosome 15. and its expression has been detected in various tissues, though its precise biological function remains unclear.
Current research suggests potential roles for LRRC69 in cellular processes such as apoptosis regulation, inflammatory responses, or extracellular matrix remodeling, given structural similarities to other LRR proteins. Antibodies targeting LRRC69 are critical tools for investigating its expression patterns, subcellular localization, and interactions. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in mapping its tissue distribution and disease associations.
While limited studies link LRRC69 to specific pathologies, its exploration in cancer, autoimmune disorders, or neurodegenerative diseases is emerging. Challenges include validating antibody specificity due to the protein’s low abundance and potential cross-reactivity with homologous LRR proteins. Further research is needed to clarify LRRC69’s functional significance and therapeutic potential, with high-quality antibodies remaining essential for advancing this field.
×
