| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein 73, Zinc finger protein 186, hZNF2, ZNF73, ZNF186 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZNF73 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ZNF73. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZNF73 (N-term)抗体的假设参考文献示例(请注意，这些为模拟内容，实际文献可能需要通过数据库进一步验证)：
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1. **标题**: *ZNF73 Expression in Gastric Cancer: A Potential Prognostic Biomarker*
**作者**: Zhang, Y. et al.
**摘要**: 本研究利用ZNF73 (N-term)特异性抗体进行免疫组化分析，发现ZNF73在胃癌组织中显著低表达，且与患者生存率下降相关，提示其可能作为预后标志物。
2. **标题**: *Functional Characterization of Zinc Finger Proteins in Transcriptional Regulation*
**作者**: Smith, J.R. et al.
**摘要**: 通过ZNF73 (N-term)抗体的Western blot和染色质免疫沉淀(ChIP)实验，揭示了ZNF73在调控靶基因启动子区的结合能力及其在表观遗传修饰中的作用。
3. **标题**: *Development and Validation of Monoclonal Antibodies Against ZNF Family Proteins*
**作者**: Lee, S. & Kim, H.
**摘要**: 该研究报道了针对ZNF73 N端表位的单克隆抗体的开发，验证了其在免疫荧光和免疫沉淀实验中的高特异性，为后续功能研究提供工具。
4. **标题**: *DNA Methylation and ZNF73 Expression in Neurodevelopmental Disorders*
**作者**: Brown, T. et al.
**摘要**: 使用ZNF73 (N-term)抗体检测脑组织样本，发现其表达异常与DNA甲基化修饰相关，提示ZNF73在神经发育中的潜在表观遗传调控机制。
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建议通过PubMed、Google Scholar等平台以关键词“ZNF73 antibody N-terminal”或“ZNF73 immunohistochemistry”检索真实文献。若研究较少，可扩展至锌指蛋白家族或相关疾病领域。
The ZNF73 (N-term) antibody is designed to target the N-terminal region of Zinc Finger Protein 73 (ZNF73), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein (ZFP) family. ZNF73 is encoded by the ZNF73 gene located on human chromosome 15q11.2. Like other KRAB-ZFPs, it likely functions as a transcriptional regulator, mediating chromatin remodeling and gene silencing through interactions with repressive complexes like KRAB-associated protein 1 (KAP1). The N-terminal KRAB domain is critical for these interactions, enabling recruitment of epigenetic modifiers to specific genomic loci.
Antibodies against the N-terminal region of ZNF73 are commonly used in research to study its expression, localization, and molecular interactions. They are validated in applications such as Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP). Due to the high homology among KRAB-ZFPs, specificity validation (e.g., knockout controls) is essential to confirm antibody reliability. ZNF73 has been implicated in studies exploring genomic imprinting, neurodevelopment, and cancer, though its precise biological roles remain under investigation. Aberrant expression or mutations in ZNF73 are also linked to Prader-Willi syndrome and certain malignancies, highlighting its potential clinical relevance. This antibody serves as a key tool for unraveling ZNF73's functions in both physiological and pathological contexts.
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