| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Acid-sensing ion channel 3, ASIC3, hASIC3, Amiloride-sensitive cation channel 3, Neuronal amiloride-sensitive cation channel 3, Testis sodium channel 1, hTNaC1, ASIC3, ACCN3, SLNAC1, TNAC1 |
| Entrez GeneID | 9311 |
| WB Predicted band size | 58.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ACCN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the N-terminal region of human ACCN3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ACCN3(N-term)抗体的3篇参考文献示例(注：文献为假设性示例，实际引用需核实)：
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1. **标题**: *Characterization of Acid-Sensing Ion Channel 3 (ASIC3) Expression in Nociceptive Neurons*
**作者**: Smith A, et al.
**摘要**: 本研究利用ACCN3 (N-term)特异性抗体，通过免疫组化技术证实ASIC3在伤害性感觉神经元中的表达，并揭示其在酸诱导疼痛中的功能，表明其N端结构域对通道膜定位至关重要。
2. **标题**: *Development of a Novel N-terminal Specific Antibody for ASIC3 and Its Application in Inflammatory Models*
**作者**: Lee C, et al.
**摘要**: 开发并验证了一种靶向ASIC3 N端的高效抗体，通过Western blot和免疫荧光证明其在炎症组织中ASIC3蛋白水平上调，为研究其在慢性疼痛中的作用提供工具。
3. **标题**: *ASIC3-Mediated Mechanosensation in Dorsal Root Ganglia: Insights from Antibody-Based Knockdown*
**作者**: Zhang D, et al.
**摘要**: 使用ACCN3 (N-term)抗体阻断ASIC3的N端功能，发现其参与背根神经节的机械敏感信号传导，提示ASIC3可能通过N端结构域调控机械痛觉传递。
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**提示**：实际文献需通过学术数据库(如PubMed、Google Scholar)以关键词“ASIC3 antibody N-terminal”或“ACCN3 antibody”检索，并筛选应用性研究。部分抗体厂商(如Abcam、Santa Cruz)的技术文档也可能提供相关引用。
The ACCN3 (N-term) antibody is a selective tool designed to target the N-terminal region of the ACCN3 protein, also known as acid-sensing ion channel 3 (ASIC3) or amiloride-sensitive cation channel 3. ACCN3 belongs to the degenerin/epithelial sodium channel (DEG/ENaC) superfamily, which plays critical roles in pH sensing, mechanotransduction, and nociception. This protein is predominantly expressed in peripheral sensory neurons, where it contributes to the detection of acidic environments, inflammatory pain, and mechanical stimuli. Dysregulation of ACCN3 has been implicated in chronic pain syndromes, neuropathies, and inflammatory conditions.
The antibody is commonly generated in hosts such as rabbits or mice using synthetic peptides or recombinant proteins corresponding to the N-terminal domain of ACCN3. Its specificity is validated through techniques like Western blotting, immunohistochemistry, and immunofluorescence, often with controls like knockout tissues to confirm minimal cross-reactivity with other ASIC isoforms (e.g., ASIC1. ASIC2). Researchers employ this antibody to study ACCN3's expression patterns, subcellular localization, and functional interactions in both physiological and pathological contexts, such as pain signaling pathways or acid-induced cellular responses. Its application extends to preclinical models exploring therapeutic targets for pain management and neurological disorders.
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