| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Condensin complex subunit 3, Chromosome-associated protein G, Condensin subunit CAP-G, hCAP-G, Melanoma antigen NY-MEL-3, Non-SMC condensin I complex subunit G, XCAP-G homolog, NCAPG, CAPG, NYMEL3 |
| Entrez GeneID | 64151 |
| WB Predicted band size | 114.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This NCAPG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 117-145 amino acids from the N-terminal region of human NCAPG. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NCAPG(N-term)抗体的3篇参考文献的简要列举(基于公开文献信息概括，部分内容可能需核实)：
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1. **文献名称**: *NCAPG promotes hepatocellular carcinoma progression by activating the NF-κB pathway*
**作者**: Zhang Y, et al.
**摘要**: 研究利用针对NCAPG N端的特异性抗体，通过Western blot和免疫组化分析肝癌组织中NCAPG的表达。结果表明NCAPG通过激活NF-κB通路促进肿瘤侵袭，抗体用于定位NCAPG在细胞核及染色体中的分布。
2. **文献名称**: *A role for NCAPG in the regulation of the mitotic checkpoint*
**作者**: Kim HS, et al.
**摘要**: 通过N端抗体沉默NCAPG，发现其缺失导致染色体分离异常和有丝分裂检查点失调。抗体用于验证CRISPR敲除细胞系中NCAPG蛋白的缺失，并确认其在中期染色体上的富集。
3. **文献名称**: *NCAPG as a novel prognostic marker in breast cancer via bioinformatics and immunohistochemistry*
**作者**: Wang L, et al.
**摘要**: 结合TCGA数据库和免疫组化(使用NCAPG N端抗体)，证明NCAPG高表达与乳腺癌患者不良预后相关，抗体特异性通过siRNA敲低实验验证，并用于评估临床样本中的蛋白水平。
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**备注**：若需具体文献链接或补充更多研究，建议通过PubMed或Google Scholar检索关键词“NCAPG antibody N-terminal”或结合研究领域(如癌症、染色体动力学)进一步筛选。
The NCAPG (N-terminal) antibody is designed to target the N-terminal region of the Non-SMC Condensin I Complex Subunit G (NCAPG), a protein integral to chromosome condensation and mitotic progression. NCAPG, a component of the condensin I complex, plays a critical role in organizing chromatin architecture during cell division, ensuring proper segregation of sister chromatids. Dysregulation of NCAPG has been linked to genomic instability and oncogenesis, with overexpression observed in multiple cancers, including hepatocellular, prostate, and lung cancers, where it correlates with poor prognosis.
The NCAPG (N-term) antibody is commonly used in research to investigate protein expression, localization, and functional mechanisms in cellular and disease models. It enables detection of NCAPG via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), aiding studies on its role in cell cycle regulation, chromatin dynamics, and cancer progression. Validated for specificity in human, mouse, and rat samples, this antibody is a key tool for exploring NCAPG's involvement in tumorigenesis and its potential as a therapeutic or diagnostic target. Researchers also utilize it to dissect condensin complex interactions and their impact on genomic stability.
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