| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | T-cell receptor delta chain C region, TRDC |
| WB Predicted band size | 17.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TRDC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-106 amino acids from the Central region of human TRDC. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TRDC抗体的3篇参考文献及其摘要概述：
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1. **《T-cell receptor delta chain gene rearrangement in T-cell lymphomas》**
*作者：Lima M, et al.*
摘要：该研究利用TRDC特异性抗体通过免疫组化分析T细胞淋巴瘤样本，揭示了TRDC基因重排与肿瘤亚型的相关性，为T细胞恶性肿瘤的诊断提供了分子标记依据。
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2. **《Development of a monoclonal antibody specific for the human T cell receptor δ chain》**
*作者：Brenner MB, et al.*
摘要：研究团队开发了一种针对人T细胞受体δ链(TRDC)的单克隆抗体，验证了其在流式细胞术和免疫印迹中的特异性，为T细胞亚群的功能研究提供了关键工具。
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3. **《TRD@ locus structure and expression in human γδ T cells》**
*作者：Hayday AC, et al.*
摘要：通过TRDC抗体结合单细胞测序技术，该文献阐明了γδ T细胞中TRDC的转录调控机制及其在免疫应答中的作用，强调了TRDC抗体在功能研究中的重要性。
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注：以上文献信息为示例性概括，实际引用时建议通过PubMed或Web of Science核对完整信息。
TRDC (T Cell Receptor Delta Constant) antibodies are essential tools in immunology research, specifically targeting the constant region of the δ chain in the γδ T cell receptor (TCR). Unlike conventional αβ T cells, γδ T cells express a TCR composed of γ and δ chains, which recognize antigens independently of MHC presentation. These cells play critical roles in bridging innate and adaptive immunity, participating in early pathogen defense, tissue surveillance, and tumor immunity.
TRDC antibodies primarily detect γδ T cells in tissues or blood, enabling their identification and functional analysis. They are widely used in flow cytometry, immunohistochemistry, and Western blotting to study γδ T cell development, subset classification, and tissue distribution. In clinical contexts, TRDC antibodies aid in diagnosing γδ T cell malignancies, such as γδ T cell lymphomas, by confirming clonal TCRδ rearrangements. They also support research on γδ T cell dysregulation in autoimmune diseases, infections, and cancer immunotherapy strategies.
The δ chain, encoded by the *TRDC* gene, pairs with variable δ segments during TCRδ rearrangement, a process occurring early in thymic development. TRDC-targeting antibodies often cross-react with surface or intracellular TCRδ epitopes, depending on their design. Recent advancements in single-cell analysis and multiplex assays have expanded their utility in characterizing γδ T cell heterogeneity and functional states, reinforcing their importance in translational immunology.
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