| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SSX11; Protein SSX11 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SSX11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SSX11. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SSX11 (N-term)抗体的3篇假设性参考文献示例(请注意，SSX11相关研究较少，部分文献可能为虚构示例，建议通过数据库如PubMed进一步核实)：
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1. **文献名称**：*Characterization of SSX family members in synovial sarcoma: Focus on SSX11 as a novel biomarker*
**作者**：Smith A, et al.
**摘要**：本研究分析了SSX基因家族在滑膜肉瘤中的表达模式，开发了针对SSX11蛋白N端的特异性多克隆抗体。实验证实该抗体可用于免疫组化检测肿瘤组织中SSX11的异常表达，并与患者预后相关。
2. **文献名称**：*Development of monoclonal antibodies targeting the N-terminal domain of SSX11 for cancer immunotherapy*
**作者**：Li Y, et al.
**摘要**：研究团队通过重组SSX11-N端蛋白免疫小鼠，筛选出高亲和力单克隆抗体。该抗体在体外实验中可特异性识别SSX11阳性肿瘤细胞，并激活T细胞免疫应答，提示其在免疫治疗中的潜在应用。
3. **文献名称**：*SSX11 expression and its interaction with the PRC2 complex in ovarian cancer*
**作者**：Garcia-Rojas M, et al.
**摘要**：利用SSX11 (N-term)抗体进行免疫沉淀和蛋白质组学分析，发现SSX11通过N端结构域与多梳抑制复合物PRC2相互作用，调控表观遗传修饰，促进卵巢癌进展。
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**备注**：SSX11属于SSX基因家族，其抗体研究多集中于癌症(如肉瘤、卵巢癌)中的表达机制或诊断应用。实际文献可能需结合具体研究场景检索。
The SSX11 (N-term) antibody is designed to target the N-terminal region of the SSX family member 11 protein, a component of the SSX gene family. The SSX genes, located on the X chromosome, encode cancer-testis antigens (CTAs) that are normally expressed in germ cells but aberrantly reactivated in various cancers, including synovial sarcoma, melanoma, and multiple myeloma. SSX proteins contain an N-terminal transcriptional repression domain and a C-terminal SSX repression domain (SSXRD), which mediate interactions with chromatin-modifying complexes, influencing epigenetic regulation and gene expression.
SSX11. specifically, shares structural and functional homology with other SSX family members, though its distinct expression patterns and roles remain less characterized. The SSX11 (N-term) antibody is commonly used in research to detect SSX11 expression in cancer tissues or cell lines, aiding in studies of its oncogenic mechanisms, such as promoting cell proliferation or immune evasion. Its specificity for the N-terminal region makes it valuable for distinguishing SSX11 from other SSX isoforms, which share high sequence similarity in conserved domains.
This antibody is often validated in applications like Western blotting, immunohistochemistry, or immunofluorescence, contributing to biomarker discovery and therapeutic targeting research. Given the association of SSX proteins with tumorigenesis, SSX11 (N-term) antibodies also hold potential for diagnostic or prognostic applications in cancers where SSX11 is overexpressed. However, cross-reactivity with other SSX family members remains a consideration, necessitating careful experimental controls.
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