| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Pregnancy-specific beta-1-glycoprotein 4, PS-beta-G-4, PSBG-4, Pregnancy-specific glycoprotein 4, Pregnancy-specific beta-1-glycoprotein 9, PS-beta-G-9, PSBG-9, Pregnancy-specific glycoprotein 9, PSG4, CGM4, PSG9 |
| Entrez GeneID | 5672 |
| WB Predicted band size | 47.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PSG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 73-100 amino acids from the N-terminal region of human PSG4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PSG4 (N-term)抗体的示例参考文献，内容基于合理推测，具体文献可能需要通过学术数据库进一步验证：
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1. **文献名称**：*"A novel monoclonal antibody against the N-terminal domain of PSG4 reveals its role in placental development"*
**作者**：Haider, S. et al.
**摘要**：本研究开发了一种靶向PSG4蛋白N端区域的新型单克隆抗体，证实其在胎盘滋养层细胞中的高表达，并发现该抗体可抑制细胞迁移，提示PSG4在胎盘形成中的潜在功能。
2. **文献名称**：*"PSG4 modulates maternal-fetal immune tolerance via its N-terminal epitope: Insights from antibody-blocking assays"*
**作者**：Mandelboim, O. et al.
**摘要**：通过抗PSG4-Nterm抗体的阻断实验，揭示了PSG4通过与母体免疫细胞(如NK细胞)相互作用，调控妊娠期免疫耐受的分子机制。
3. **文献名称**：*"Development of a PSG4-specific ELISA for early detection of preeclampsia using N-terminal targeted antibodies"*
**作者**：Fisher, P.B. et al.
**摘要**：研究团队利用PSG4-Nterm抗体开发了一种高灵敏度ELISA检测方法，证实妊娠早期PSG4水平与子痫前期风险相关，为临床诊断提供了新工具。
4. **文献名称**：*"Structural and functional characterization of PSG4-Nterm antibody complexes by cryo-EM"*
**作者**：Zhang, L. et al.
**摘要**：通过冷冻电镜解析了PSG4-Nterm抗体复合物的三维结构，阐明了其结合表位，并验证了该抗体在肿瘤微环境中对PSG4过表达的检测潜力。
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**备注**：以上文献为示例性内容，实际引用时建议通过PubMed、Web of Science等平台以关键词“PSG4 antibody”“Pregnancy-Specific Glycoprotein 4”或“CEACAM18”(PSG4的别称)检索最新研究。
PSG4 (N-term) Antibody Background:
The PSG4 (Pregnancy-Specific Glycoprotein 4) antibody targets the N-terminal region of the PSG4 protein, a member of the pregnancy-specific glycoprotein family. PSGs, primarily expressed in placental syncytiotrophoblasts, are critical in modulating maternal immune tolerance during pregnancy and promoting placental development. PSG4. encoded by the CEACAM19 gene, belongs to the carcinoembryonic antigen (CEA) family and shares structural similarities with other PSG members, including immunoglobulin-like domains.
Functionally, PSG4 is implicated in immune regulation, angiogenesis, and trophoblast invasion. Its elevated expression during gestation suggests roles in maintaining fetal-maternal interface homeostasis. Recent studies also explore PSG4's potential involvement in cancer progression, as aberrant expression has been observed in certain malignancies.
The PSG4 (N-term) antibody, typically developed in rabbit or mouse hosts, is designed to recognize epitopes within the N-terminal region, enabling detection in applications like Western blotting, immunohistochemistry (IHC), and ELISA. It serves as a tool for investigating PSG4's biological roles in pregnancy-related disorders (e.g., preeclampsia, intrauterine growth restriction) and cancer biology. Validation via knockout controls or peptide blocking assays ensures specificity. Researchers utilize this antibody to study PSG4 expression patterns, cellular localization, and interactions, contributing to broader insights into reproductive health and disease mechanisms.
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