| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BTB/POZ domain-containing protein KCTD17, KCTD17 |
| Entrez GeneID | 79734 |
| WB Predicted band size | 35.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This KCTD17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-136 amino acids from the Central region of human KCTD17. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于KCTD17抗体的3篇代表性文献摘要(注：文献为虚拟示例，实际引用需核实)：
1. **文献名称**：*KCTD17 interacts with cullin-3 to regulate neuronal proteostasis*
**作者**：Puppo, M. et al.
**摘要**：研究利用KCTD17抗体进行免疫共沉淀和免疫荧光实验，发现KCTD17作为E3泛素连接酶复合体成员，通过与cullin-3结合调控神经细胞中错误折叠蛋白的泛素化降解，其表达异常可能导致神经退行性疾病。
2. **文献名称**：*KCTD17 promotes tumor migration via Wnt/β-catenin signaling in colorectal cancer*
**作者**：Li, X. et al.
**摘要**：通过Western blot(使用KCTD17抗体)和基因沉默技术，揭示KCTD17在结直肠癌中高表达，并通过激活Wnt通路促进肿瘤细胞迁移，提示其作为潜在治疗靶点。
3. **文献名称**：*KCTD17 deficiency disrupts primary cilium formation in developmental disorders*
**作者**：Bayés, M. et al.
**摘要**：利用KCTD17抗体的免疫组化分析发现，KCTD17缺失导致小鼠模型中纤毛形成缺陷，与胚胎发育异常相关，为先天性畸形提供了分子机制解释。
(提示：实际研究中请通过PubMed或Google Scholar以“KCTD17 antibody”为关键词检索最新文献。)
The KCTD17 antibody is a research tool designed to detect and study the potassium channel tetramerization domain-containing 17 (KCTD17) protein, a member of the KCTD family implicated in diverse cellular processes. KCTD17 is characterized by a conserved N-terminal BTB domain, which facilitates protein-protein interactions, and a variable C-terminal region. It plays roles in ubiquitination pathways by interacting with cullin-3. a component of E3 ubiquitin ligase complexes, thereby regulating substrate degradation. Dysregulation of KCTD17 has been linked to neurological disorders, including autism spectrum disorders and schizophrenia, as well as cancers such as glioblastoma and breast cancer, where it may influence cell proliferation or apoptosis.
The antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess KCTD17 expression levels, localization, and interactions in tissues or cell lines. Its development has been critical in elucidating KCTD17’s tissue-specific functions and pathological mechanisms. Studies using this antibody have revealed its involvement in neural development and synaptic plasticity, while cancer research highlights its dual role as either an oncogene or tumor suppressor, depending on cellular context. Researchers also employ KCTD17 antibodies to explore its regulatory networks, including interactions with signaling pathways like Wnt/β-catenin or Notch. Validated for specificity across human and model organisms, the antibody remains pivotal in advancing molecular and clinical insights into KCTD17-related diseases.
×
