| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Coatomer subunit beta', Beta'-coat protein, Beta'-COP, p102, COPB2 |
| Entrez GeneID | 9276 |
| WB Predicted band size | 102.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This COPB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 814-843 amino acids from the C-terminal region of human COPB2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于COPB2抗体的模拟参考文献示例(注：以下为虚拟文献，仅供示例参考)：
1. **标题**：*COPB2 promotes hepatocellular carcinoma progression by regulating ER-Golgi transport*
**作者**：Li, X.; Wang, Y.; Chen, J.
**摘要**：该研究利用COPB2抗体进行Western blot和免疫组化分析，发现COPB2在肝癌组织中高表达，并通过调控内质网-高尔基体囊泡运输促进肿瘤细胞侵袭和转移。
2. **标题**：*COPB2 as a potential biomarker in gastric cancer: Insights from immunohistochemical analysis*
**作者**：Zhang, H.; Liu, R.; Sato, K.
**摘要**：通过COPB2抗体进行免疫组化染色，揭示COPB2在胃癌组织中的过表达与患者预后不良显著相关，提示其可作为胃癌诊断的潜在生物标志物。
3. **标题**：*COPB2 knockdown disrupts Golgi structure and impairs cell migration in breast cancer models*
**作者**：Gupta, S.; Patel, M.; Rodriguez, A.
**摘要**：研究使用COPB2抗体验证siRNA敲低效果，证明COPB2缺失导致高尔基体结构异常，并通过抑制细胞迁移影响乳腺癌进展。
4. **标题**：*COPB2 interacts with EGFR to modulate autophagy in lung adenocarcinoma*
**作者**：Kim, T.; Park, S.; Lee, J.
**摘要**：通过COPB2抗体进行免疫共沉淀(Co-IP)实验，发现COPB2与EGFR相互作用，调控自噬通路，从而影响肺腺癌细胞的化疗耐药性。
(注：实际文献需通过PubMed、Google Scholar等平台检索确认。)
The COPB2 antibody targets the Coatomer Protein Complex Subunit Beta 2 (COPB2), a key component of the COPI (coatomer protein complex I) vesicle system involved in intracellular trafficking. COPI mediates retrograde transport of proteins and lipids from the Golgi apparatus to the endoplasmic reticulum, ensuring proper sorting, recycling, and maintenance of organelle integrity. COPB2. as a β-subunit of COPI, plays a critical role in stabilizing the complex and facilitating cargo recognition. Dysregulation of COPB2 has been linked to diseases, including cancer and neurodegenerative disorders, due to its impact on cellular homeostasis.
Antibodies against COPB2 are widely used in research to study its expression, localization, and function. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Recent studies highlight COPB2's oncogenic potential, showing overexpression in cancers such as breast, lung, and liver malignancies, where it correlates with poor prognosis. Additionally, COPB2 is implicated in viral infections (e.g., hepatitis C, SARS-CoV-2) by interacting with viral proteins to facilitate replication. These findings position COPB2 as a potential therapeutic target or biomarker. Antibodies are typically generated in rabbits or mice using recombinant COPB2 protein fragments, ensuring specificity for experimental validation. Ongoing research aims to elucidate COPB2's mechanistic roles in disease pathways and explore its diagnostic or therapeutic utility.
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