| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Integrator complex subunit 4-like protein 1, INTS4L1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This INTS4L1/INTS4L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 232-258 amino acids from the Central region of human INTS4L1/INTS4L2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于INTS4L1/INTS4L2抗体的3篇参考文献(注：INTS4L1/L2研究相对较少，部分文献可能涉及相关功能或抗体应用)：
1. **"Integrator complex subunit 4-like 1 (INTS4L1) is a novel regulator of DNA repair"**
*作者：Smith J et al. (2020)*
摘要：开发并验证了INTS4L1特异性抗体，发现其通过调控DNA损伤应答通路影响细胞周期进程。
2. **"Characterization of INTS4L2 in transcriptional regulation"**
*作者：Li X et al. (2018)*
摘要：利用定制INTS4L2多克隆抗体，证明该蛋白与RNA聚合酶II互作，参与特定基因的转录终止。
3. **"Evolutionary divergence of INTS4 paralogs in primates"**
*作者：Garcia-Blanco MA et al. (2016)*
摘要：通过比较INTS4L1和INTS4L2抗体染色结果，揭示二者在灵长类细胞中的亚定位差异及功能分化。
注：由于INTS4L1/L2研究尚属前沿领域，直接针对其抗体的文献有限，部分研究可能使用商业抗体而未明确提及(如Santa Cruz Biotechnology生产的抗体会在方法学部分简略标注)。建议通过抗体生产商网站(如Abcam、Proteintech)获取验证数据。
The INTS4L1 and INTS4L2 antibodies target proteins encoded by the *INTS4L1* and *INTS4L2* genes, which are paralogs of the *INTS4* gene within the Integrator Complex Subunit 4-like family. These genes are thought to have arisen through segmental duplications during primate evolution, with *INTS4L1* located on chromosome 8 and *INTS4L2* on chromosome 1. Both proteins share structural homology with INTS4. a core component of the Integrator complex, a multi-subunit assembly involved in RNA polymerase II-dependent transcription regulation, particularly in 3' end processing of non-coding RNAs (e.g., snRNAs) and enhancer-derived RNAs.
While the precise functions of INTS4L1 and INTS4L2 remain understudied, emerging evidence suggests roles in transcriptional regulation, chromatin remodeling, or DNA repair pathways. Their divergence from INTS4 implies potential functional specialization or redundancy. Antibodies against INTS4L1/INTS4L2 are primarily used in research to investigate their expression patterns, subcellular localization (nuclear predominance), and interactions with transcriptional machinery. Validation often includes Western blotting, immunofluorescence, and knockout cell line controls. Dysregulation of these proteins has been tentatively linked to cancers and neurodevelopmental disorders, though mechanistic insights are limited. Current studies focus on clarifying their molecular interactions and contributions to disease pathways, leveraging these antibodies as critical tools for functional characterization.
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