| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Putative eukaryotic translation initiation factor 2 subunit 3-like protein, Eukaryotic translation initiation factor 2 subunit gamma A, eIF-2-gamma A, eIF-2gA, EIF2S3L |
| WB Predicted band size | 51.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This EIF2S3L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-299 amino acids from the Central region of human EIF2S3L. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于EIF2S3L抗体的假设性参考文献示例(注：EIF2S3L相关研究较少，以下内容为模拟，实际引用请核实文献真实性)：
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1. **文献名称**: *Characterization of a novel polyclonal antibody against human EIF2S3L for translational regulation studies*
**作者**: Smith A, et al.
**摘要**: 本研究开发并验证了一种针对人EIF2S3L蛋白的多克隆抗体，通过免疫印迹和免疫荧光实验证实其特异性。该抗体成功用于检测多种细胞系中EIF2S3L的亚细胞定位，为研究其在真核翻译起始中的潜在功能提供工具。
2. **文献名称**: *EIF2S3L expression in neural development: Insights from antibody-based profiling*
**作者**: Chen L, et al.
**摘要**: 利用定制的小鼠单克隆EIF2S3L抗体，研究发现该蛋白在小鼠胚胎神经发育阶段高表达，提示其可能参与神经干细胞的增殖分化调控。抗体特异性通过基因敲除细胞系验证。
3. **文献名称**: *Role of EIF2S3L in hepatocellular carcinoma: An immunohistochemical study*
**作者**: Wang Y, et al.
**摘要**: 采用商业化兔源EIF2S3L抗体分析肝癌组织样本，发现EIF2S3L表达与患者预后负相关。研究验证了抗体的适用性，并探讨其作为潜在生物标志物的可能性。
4. **文献名称**: *Comparative analysis of EIF2S3 family members using isoform-specific antibodies*
**作者**: Gupta R, et al.
**摘要**: 通过对比EIF2S3家族蛋白(包括EIF2S3L)的抗体特异性，揭示了不同亚型在应激反应中的差异表达。研究强调抗体选择对准确解析翻译调控机制的重要性。
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**提示**：以上内容为示例，EIF2S3L相关研究目前公开数据有限，建议通过基因别名(如NCBI查询)或抗体供应商(如CiteAb)获取最新文献。实际研究中需严格验证抗体特异性(如敲除/敲低实验)。
The EIF2S3L antibody targets the Eukaryotic Translation Initiation Factor 2 Subunit 3 Like (EIF2S3L), a protein implicated in regulating translation initiation. EIF2S3L, also known as eIF2γ-like, shares structural homology with the gamma subunit of eIF2. a core component of the translation initiation complex. While eIF2 is essential for delivering initiator tRNA to ribosomes, EIF2S3L is thought to function in specialized translation pathways or stress responses, though its precise role remains under investigation. Studies suggest it may modulate protein synthesis under specific cellular conditions, such as nutrient deprivation or stress, potentially influencing cell survival or apoptosis.
Antibodies against EIF2S3L are valuable tools for exploring its expression, localization, and interactions. They enable detection via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Research applications include investigating translational regulation in diseases like cancer, neurodegeneration, or viral infections, where dysregulated protein synthesis is a hallmark. Some studies also probe its tissue-specific expression patterns or interplay with eIF2 subunits. Validation of these antibodies often involves knockout controls or siRNA-mediated silencing to confirm specificity. As EIF2S3L's functions are still being elucidated, its antibody serves as a critical reagent for uncovering its biological and pathological significance in translational control mechanisms.
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