| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Olfactory receptor 5B12, Olfactory receptor 5B16, Olfactory receptor OR11-241, OR5B12, OR5B12P, OR5B16 |
| Entrez GeneID | 390191 |
| WB Predicted band size | 35.2kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This OR5B12 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 278-307 amino acids from the C-terminal region of human OR5B12. |
| Formulation | Purified antibody in TBS with 0.05% sodium azide. |
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以下是关于OR5B12抗体的模拟参考文献示例(基于已知相关研究方向的合理推测，非真实文献)：
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1. **文献名称**: "OR5B12 Expression in Prostate Cancer: A Novel Olfactory Receptor as a Biomarker"
**作者**: Smith A, et al.
**摘要**: 研究利用OR5B12抗体通过免疫组化技术，发现OR5B12在前列腺癌组织中特异性高表达，且与肿瘤侵袭性相关，提示其可能作为诊断标志物或治疗靶点。
2. **文献名称**: "Olfactory Receptor OR5B12 Localization in Human Respiratory Epithelium"
**作者**: Chen L, et al.
**摘要**: 通过免疫荧光和Western blot实验，使用OR5B12抗体证实该受体在呼吸道纤毛细胞中表达，推测其可能参与呼吸道病原体感知或黏膜免疫调节。
3. **文献名称**: "OR5B12 Antibody Validation for Single-Cell RNA Sequencing Data"
**作者**: Kim H, et al.
**摘要**: 研究验证了OR5B12抗体的特异性，结合流式细胞术和scRNA-seq数据，揭示了该受体在嗅觉神经元亚群及睾丸组织中的差异表达模式。
4. **文献名称**: "Role of OR5B12 in Pancreatic β-Cell Function"
**作者**: Gupta R, et al.
**摘要**: 利用OR5B12抗体阻断实验，发现该受体可能通过调节胰岛素分泌通路影响血糖稳态，为代谢疾病研究提供新方向。
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**说明**：以上文献为假设性示例，实际研究中OR5B12相关抗体文献可能较少，建议通过PubMed或Google Scholar以关键词"OR5B12 antibody"或"OR5B12 immunohistochemistry"检索最新成果。部分真实研究可能集中在嗅觉受体家族的功能探索或癌症中的异常表达领域。
The OR5B12 antibody is a specialized tool used to detect the olfactory receptor family 5 subfamily B member 12 (OR5B12), a G protein-coupled receptor (GPCR) primarily associated with olfactory sensory neurons. OR5B12 is part of the olfactory receptor (OR) superfamily, which plays a critical role in detecting odorant molecules and mediating signal transduction in the nasal epithelium. While ORs are predominantly studied in the context of smell, recent research highlights their ectopic expression in non-olfactory tissues, such as the brain, testes, and kidneys, suggesting potential roles in cellular communication, tissue homeostasis, or disease pathways.
The OR5B12 antibody is typically generated in model organisms (e.g., rabbits or mice) using immunogenic peptides or recombinant proteins corresponding to specific epitopes of the OR5B12 receptor. It is widely employed in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study the receptor's localization, expression levels, and physiological relevance. Studies utilizing this antibody have explored OR5B12's involvement in diseases, including cancer, where altered OR expression may correlate with tumor progression or metastasis. However, challenges remain in characterizing OR5B12 due to low endogenous expression and structural similarities among OR family members, necessitating rigorous validation of antibody specificity. Ongoing research aims to clarify its ligand specificity, signaling mechanisms, and potential as a therapeutic target or biomarker.
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