| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Stromal membrane-associated protein 1, SMAP1 |
| Entrez GeneID | 60682 |
| WB Predicted band size | 50.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SMAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-113 amino acids from the N-terminal region of human SMAP1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SMAP1 (N-term)抗体的3篇参考文献示例(注：文献为模拟概括，仅供参考)：
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1. **文献名称**: *SMAP1 regulates mitotic progression through microtubule stability*
**作者**: Tanaka et al.
**摘要**: 本研究使用SMAP1 (N-term)抗体(兔多克隆抗体)通过免疫印迹和免疫荧光技术，证实SMAP1蛋白通过与微管结合调控有丝分裂进程。实验显示SMAP1在HeLa细胞分裂中期富集，敲低SMAP1导致染色体排列异常，提示其功能依赖N端结构域。
2. **文献名称**: *The role of SMAP1 in DNA damage response*
**作者**: Chen et al.
**摘要**: 该文献利用SMAP1 (N-term)特异性抗体(货号：ab12345)进行免疫沉淀实验，发现SMAP1的N端区域与ATM激酶相互作用，参与DNA损伤修复通路。研究通过Western blot验证SMAP1在电离辐射后的磷酸化修饰变化。
3. **文献名称**: *SMAP1 deficiency leads to neurodevelopmental disorders in mice*
**作者**: Müller et al.
**摘要**: 作者通过SMAP1 (N-term)抗体对小脑组织切片进行免疫组化分析，发现SMAP1在小脑颗粒神经元中高表达。基因敲除小鼠表现出运动协调障碍，提示SMAP1的N端功能对神经系统发育至关重要。
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**备注**：以上文献信息为示例，实际研究中请通过PubMed或Google Scholar以“SMAP1 antibody N-terminal”等关键词检索最新论文，并核对抗体货号及实验细节。
The SMAP1 (N-term) antibody is designed to target the N-terminal region of Small ArfGAP 1 (SMAP1), a protein involved in regulating intracellular membrane trafficking. SMAP1 functions as a GTPase-activating protein (GAP) for ADP-ribosylation factor (Arf) family proteins, which are critical for vesicle formation, cytoskeletal organization, and receptor sorting. Specifically, SMAP1 regulates clathrin-coated vesicle assembly and endosomal sorting by inactivating Arf6. influencing processes like endocytosis and receptor recycling. The N-terminal region of SMAP1 contains conserved domains essential for its subcellular localization and interaction with partner proteins.
This antibody is commonly used in research to study SMAP1 expression, localization, and function in cellular models. It is validated for applications such as Western blotting, immunofluorescence, and immunoprecipitation, often in human, mouse, or rat samples. Studies utilizing this antibody have explored SMAP1's roles in cancer progression, neuronal development, and immune responses, as aberrant SMAP1 activity is linked to tumor suppression, neurodevelopmental disorders, and immune dysregulation. By detecting the N-terminal epitope, the antibody helps differentiate full-length SMAP1 from potential splice variants or cleavage products, aiding in mechanistic studies of its regulatory pathways. Commercial sources typically provide species reactivity and application-specific validation data.
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