| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | PRAME family member 11, PRAMEF11 |
| Entrez GeneID | 440560 |
| WB Predicted band size | 55.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PRAMEF11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-214 amino acids from the Central region of human PRAMEF11. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PRAMEF11抗体的示例参考文献(内容为虚构示例，供参考)：
1. **文献名称**：*Characterization of PRAMEF11 Antibody for Detection in Germ Cell Tumors*
**作者**：Smith A, et al.
**摘要**：本研究开发并验证了一种针对PRAMEF11蛋白的高特异性单克隆抗体，通过免疫组化和Western blot技术证实其在睾丸生殖细胞肿瘤中的高表达，提示其作为潜在诊断标志物的可能性。
2. **文献名称**：*PRAMEF11 Expression Profiling in Cancer via Novel Polyclonal Antibody*
**作者**：Chen L, et al.
**摘要**：研究团队制备了兔源多克隆抗体，用于分析PRAMEF11在多种癌症组织中的表达差异，发现其在肺癌和黑色素瘤中显著上调，可能与肿瘤增殖通路相关。
3. **文献名称**：*Functional Role of PRAMEF11 in Epigenetic Regulation Revealed by Antibody-Based Assays*
**作者**：Gupta R, et al.
**摘要**：通过特异性抗体阻断PRAMEF11蛋白功能，研究其在表观遗传修饰中的作用，发现其可能通过调控组蛋白甲基化影响癌细胞分化。
4. **文献名称**：*Development of a PRAMEF11-Specific ELISA Kit for Clinical Biomarker Screening*
**作者**：Wang Y, et al.
**摘要**：基于新开发的PRAMEF11抗体建立ELISA检测方法，验证其在血清样本中的灵敏度，初步结果显示其在早期癌症患者中具有较高的检出率。
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**备注**：以上内容为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索关键词(如“PRAMEF11 antibody”“PRAMEF11 cancer expression”)获取。若研究较新或较冷门，建议扩展检索至PRAMEF家族或表观遗传相关抗体应用文献。
The PRAMEF11 (PReferentially expressed Antigen in MElanoma Family member 11) antibody is a tool used to study the PRAMEF protein family, which shares homology with cancer-testis antigens (CTAs) often overexpressed in malignancies. PRAMEF genes, located on human chromosome 1p36.22. are implicated in germline development and epigenetic regulation, though their exact biological roles remain unclear. PRAMEF11. a member of this family, is thought to participate in transcriptional regulation, potentially influencing cell proliferation or apoptosis. Its expression is typically restricted to germ cells under normal conditions but has been observed ectopically in certain cancers, suggesting a possible link to oncogenesis or tumor progression.
Research using PRAMEF11 antibodies focuses on elucidating its expression patterns, subcellular localization, and interactions with epigenetic modifiers. Studies have explored its role in DNA methylation dynamics and chromatin remodeling, particularly in contexts like melanoma, glioblastoma, or testicular germ cell tumors. The antibody is commonly employed in techniques such as Western blotting, immunohistochemistry, or immunofluorescence to detect PRAMEF11 in clinical samples or cell models. Challenges include cross-reactivity with other PRAMEF members due to sequence homology. Further investigations aim to clarify its functional significance, therapeutic potential, or utility as a diagnostic biomarker in cancers with aberrant PRAMEF11 expression.
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