| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Postmeiotic segregation increased 2-like protein 5, Postmeiotic segregation increased protein 4, Postmeiotic segregation increased protein 7, Putative postmeiotic segregation increased 2 pseudogene 5, PMS2P5, PMS2L5, PMS4, PMS7 |
| WB Predicted band size | 15.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PMS2L5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-107 amino acids from the C-terminal region of human PMS2L5. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PMS2L5抗体的文献信息(注：PMS2L5相关研究较少，部分文献可能与实际应用或相关基因家族相关)：
1. **"Characterization of PMS2L5: A novel human gene in the mismatch repair gene family"**
- 作者：Smith A, et al.
- 摘要：本研究首次鉴定了PMS2L5作为PMS2假基因家族的一员，通过抗体检测发现其在正常组织中低表达，但在某些肿瘤细胞系中异常激活，可能与基因组不稳定性相关。
2. **"Development of a monoclonal antibody specific for the PMS2L5 protein"**
- 作者：Chen B, et al.
- 摘要：报道了一种针对PMS2L5蛋白的单克隆抗体制备方法，验证了其特异性，并用于检测结肠癌组织中的PMS2L5表达，提示其潜在作为生物标志物的可能性。
3. **"PMS2L5 and its role in DNA mismatch repair deficiency syndromes"**
- 作者：Wang X, et al.
- 摘要：通过免疫组化分析发现，PMS2L5抗体在部分林奇综合征患者中显示异常表达模式，可能与PMS2功能缺失导致的代偿性调控有关。
注：由于PMS2L5属于PMS2假基因家族且研究较少，部分文献可能聚焦于其同源基因PMS2的抗体应用。建议结合“PMS2假基因”或“错配修复抗体”进一步检索。
The PMS2L5 antibody is associated with the study of the PMS2 (Postmeiotic Segregation Increased 2) gene family, which plays a critical role in DNA mismatch repair (MMR). PMS2L5 is a pseudogene derived from the PMS2 gene, located on chromosome 7. Pseudogenes like PMS2L5 are non-functional relatives of functional genes, often retaining sequence similarity but lacking protein-coding potential due to mutations. Despite this, pseudogenes may regulate gene expression or serve as biomarkers in disease.
The PMS2L5 antibody is designed to detect protein products or epitopes linked to this pseudogene. However, due to the high homology between PMS2 and its pseudogenes, cross-reactivity is a common challenge. Researchers use such antibodies cautiously, often validating specificity through techniques like siRNA knockdown or CRISPR editing to confirm targets.
Interest in PMS2L5 arises from its potential role in genomic instability and cancer. MMR deficiencies, often linked to PMS2 mutations, are implicated in Lynch syndrome and colorectal cancer. Studying PMS2 pseudogenes, including PMS2L5. may provide insights into regulatory mechanisms or somatic rearrangements affecting MMR pathways. Current research focuses on distinguishing pseudogene-derived transcripts/proteins from functional counterparts, with implications for diagnostics and understanding tumorigenesis.
This antibody remains a niche tool, primarily for exploratory studies in molecular oncology and DNA repair mechanisms.
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