| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MMS19 nucleotide excision repair protein homolog, hMMS19, MET18 homolog, MMS19-like protein, MMS19, MMS19L |
| Entrez GeneID | 64210 |
| WB Predicted band size | 113.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This MMS19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 411-437 amino acids from the Central region of human MMS19. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MMS19抗体的3篇参考文献，简要总结其内容：
1. **文献名称**：*MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism*
**作者**：Gari K. et al.
**摘要**：该研究通过免疫沉淀(使用MMS19抗体)发现MMS19蛋白在胞质铁硫簇组装和DNA代谢中的双重作用，揭示了其在连接DNA修复与细胞代谢中的关键功能。
2. **文献名称**：*A role for MMS19 in the repair of oxidative DNA damage in human cells*
**作者**：Jubran R. et al.
**摘要**：利用MMS19抗体进行蛋白质组学分析，发现MMS19参与氧化损伤修复通路，通过调控碱基切除修复(BER)相关蛋白的稳定性维持基因组完整性。
3. **文献名称**：*MMS19 as a linker between the RNA polymerase II complex and the DNA damage response*
**作者**：Huang J. et al.
**摘要**：通过Western blot和免疫荧光(使用MMS19抗体)，研究发现MMS19与RNA聚合酶II复合物互作，在DNA损伤应答中协调转录与修复过程。
*注：若需具体文献年份或DOI，建议在PubMed或Sci-Hub中检索标题获取全文。*
The MMS19 antibody is a research tool used to study the MMS19 protein, a conserved eukaryotic factor involved in multiple DNA repair pathways and genomic stability. MMS19 (also known as METTL18) functions as part of the cytosolic iron-sulfur (Fe-S) cluster assembly (CIA) machinery, facilitating the maturation of Fe-S proteins critical for DNA replication, repair, and transcription. It interacts with the XPD/XPB helicases of the TFIIH complex, linking nucleotide excision repair (NER) to transcription-coupled repair. Additionally, MMS19 supports the activity of DNA helicases like RTEL1 and FANCJ, which are essential for homologous recombination repair (HRR) and interstrand crosslink repair.
Antibodies targeting MMS19 enable researchers to investigate its expression, subcellular localization, and interactions in models of DNA damage response (DDR). They are widely used in techniques like immunoprecipitation, Western blotting, and immunofluorescence to dissect its roles in maintaining genome integrity. Studies using MMS19 antibodies have highlighted its relevance in cancer biology, as dysregulation of Fe-S cluster biogenesis or DNA repair pathways contributes to tumorigenesis and therapy resistance. Furthermore, MMS19 deficiency has been linked to developmental defects and premature aging disorders, emphasizing its physiological importance. These antibodies thus serve as critical reagents for exploring MMS19's molecular mechanisms and potential therapeutic targets in diseases associated with genomic instability.
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