| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Leucine-rich repeat-containing protein 14B, LRRC14B |
| Entrez GeneID | 389257 |
| WB Predicted band size | 56.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This LRRC14B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-81 amino acids from the N-terminal region of human LRRC14B. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于LRRC14B (N-term)抗体的示例参考文献(注：因LRRC14B研究相对较少，以下内容为模拟示例，实际文献需通过PubMed等数据库验证)：
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1. **文献名称**: *"LRRC14B regulates cell cycle progression through interaction with CDK1"*
**作者**: Smith A, et al.
**摘要**: 本研究利用LRRC14B (N-term)抗体进行免疫共沉淀和Western blot分析，发现LRRC14B通过与CDK1相互作用调控G2/M期转换，揭示了其在细胞周期中的潜在功能。
2. **文献名称**: *"LRRC14B expression is downregulated in colorectal cancer and correlates with patient prognosis"*
**作者**: Li Y, et al.
**摘要**: 通过免疫组化(使用N端特异性LRRC14B抗体)和生存分析，发现LRRC14B在结直肠癌组织中表达显著降低，其低表达与患者不良预后相关，提示其可能作为肿瘤抑制因子。
3. **文献名称**: *"Proteomic analysis of LRRC14B-associated protein complexes in neuronal cells"*
**作者**: Garcia R, et al.
**摘要**: 结合LRRC14B (N-term)抗体的免疫沉淀和质谱技术，鉴定出LRRC14B在神经元中与突触相关蛋白(如PSD95)存在相互作用，暗示其参与突触可塑性调控。
4. **文献名称**: *"LRRC14B variants and antibody validation in autoimmune disorders"*
**作者**: Chen H, et al.
**摘要**: 本研究验证了LRRC14B抗体的特异性，并发现携带LRRC14B基因突变的患者血清中自身抗体水平升高，提示其可能与系统性红斑狼疮等自身免疫疾病相关。
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**注意**：以上为模拟文献，实际研究中LRRC14B相关报道较少。建议通过**PubMed**或**Google Scholar**以关键词“LRRC14B antibody”或“LRRC14B function”检索最新文献，并优先选择近5年、高影响因子的研究。若需具体文献协助，可提供更多背景信息进一步筛选。
The LRRC14B (N-term) antibody is a targeted immunological tool designed to recognize the N-terminal region of the leucine-rich repeat-containing protein 14B (LRRC14B). LRRC14B belongs to the leucine-rich repeat (LRR) protein family, characterized by repetitive sequences involved in protein-protein interactions, signaling pathways, and cellular processes such as adhesion, development, and immune response. While the precise biological function of LRRC14B remains under investigation, studies suggest its potential roles in cell cycle regulation, transcriptional modulation, or disease-associated pathways, including cancer and neurological disorders.
This antibody is commonly utilized in research applications like Western blotting, immunohistochemistry, and immunofluorescence to detect LRRC14B expression levels, localization, and interactions in tissues or cell lines. Its specificity for the N-terminal domain ensures minimal cross-reactivity with other LRR family members, making it a critical reagent for distinguishing LRRC14B from structurally related proteins. The N-terminal region may contain unique structural motifs or functional sites critical for LRRC14B’s activity, such as binding interfaces or regulatory domains. Researchers often employ this antibody to explore LRRC14B’s involvement in cellular mechanisms, disease biomarkers, or therapeutic targets. Validation data, including knockout controls or peptide-blocking assays, are essential to confirm its specificity, given the complexity of LRR protein homology. Overall, the LRRC14B (N-term) antibody serves as a vital tool for elucidating the protein’s role in health and disease.
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