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Rabbit Polyclonal MouseAvpr1b Antibody

  • 中文名: Mouse Avpr1b抗体
  • 别    名: Vasopressin V1b receptor, V1bR, AVPR V1b, AVPR V3, Antidiuretic hormone receptor 1b, Vasopressin V3 receptor, Avpr1b, V1br
货号: IPDX32046
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesVasopressin V1b receptor, V1bR, AVPR V1b, AVPR V3, Antidiuretic hormone receptor 1b, Vasopressin V3 receptor, Avpr1b, V1br
Entrez GeneID26361
WB Predicted band size46.5kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityMouse
ImmunogenThis Mouse Avpr1b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 216-242 amino acids from the Central region of mouse Avpr1b.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于Mouse Avpr1b抗体的3篇参考文献及其摘要内容:

1. **文献名称**:*"Vasopressin 1b receptor knockout reduces aggressive behavior in male mice"*

**作者**:Wersinger SR, et al.

**摘要**:该研究通过基因敲除小鼠模型,分析了Avpr1b在攻击行为中的作用。文中使用特异性Avpr1b抗体进行免疫组化和Western blot验证,证实敲除小鼠中受体蛋白的缺失,并发现其攻击性行为显著降低,提示Avpr1b在社交行为调控中的关键作用。

2. **文献名称**:*"Characterization of a novel monoclonal antibody specific for the mouse vasopressin V1b receptor"*

**作者**:Stevenson KR, et al.

**摘要**:本研究报道了一种针对小鼠Avpr1b的单克隆抗体的开发与验证。通过免疫印迹和免疫荧光实验,证明该抗体在脑垂体和海马组织中特异性识别Avpr1b,且不与Avpr1a或Avpr2发生交叉反应,为后续受体定位研究提供了可靠工具。

3. **文献名称**:*"Role of vasopressin V1b receptor in stress-related behaviors: Insights from antibody-based receptor localization"*

**作者**:Hernandez CC, et al.

**摘要**:研究利用Avpr1b特异性抗体探究该受体在小鼠中枢神经系统的分布及其在应激反应中的功能。免疫组化显示Avpr1b广泛表达于下丘脑和杏仁核,并通过行为学实验结合抗体阻断技术,揭示了其在焦虑样行为中的调控机制。

4. **文献名称**:*"Pharmacological profile and functional validation of selective V1b receptor antibodies in murine models"*

**作者**:Yamaguchi Y, et al.

**摘要**:本文系统评估了多种Avpr1b抗体的选择性及药理学应用。通过基因敲除组织对照和受体转染细胞系验证抗体特异性,并利用这些抗体证实Avpr1b在促肾上腺皮质激素释放中的关键作用,为研究受体信号通路提供方法学支持。

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以上文献聚焦于抗体的开发、特异性验证及在行为学或生理机制研究中的应用,可作为Avpr1b相关实验的参考依据。

背景信息

The mouse Avpr1b antibody is a specialized tool designed to detect and study the arginine vasopressin receptor 1B (Avpr1b), a G protein-coupled receptor (GPCR) primarily expressed in the central nervous system. Avpr1b plays a critical role in regulating stress responses, social behaviors, and emotional states by mediating the effects of arginine vasopressin (AVP) and corticotropin-releasing hormone (CRH). It is implicated in modulating the hypothalamic-pituitary-adrenal (HPA) axis, influencing adrenocorticotropic hormone (ACTH) release, and participating in neuroendocrine pathways. The antibody is typically generated using immunogens derived from synthetic peptides or recombinant proteins corresponding to specific epitopes of the mouse Avpr1b extracellular or intracellular domains. It is validated for applications such as Western blotting, immunohistochemistry, and immunofluorescence to assess receptor localization, expression levels, and dynamic changes under physiological or pathological conditions. Researchers utilize this antibody to explore Avpr1b's involvement in anxiety, depression, aggression, and autism spectrum disorders, as well as its potential as a therapeutic target. Specificity is confirmed using Avpr1b knockout controls to ensure minimal cross-reactivity with related receptors like Avpr1a. Its development supports advances in neurobiology, behavioral studies, and psychopharmacology research.

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