| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cystatin-C, Cystatin-3, Cst3 |
| Entrez GeneID | 13010 |
| WB Predicted band size | 15.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This Mouse Cst3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-65 amino acids from the Central region of mouse Cst3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与小鼠Cst3(胱抑素C)抗体相关的参考文献摘要：
1. **文献名称**：Cystatin C deficiency promotes inflammation in atherosclerotic plaques of ApoE-deficient mice
**作者**：Shi GP et al.
**摘要**：该研究利用Cst3基因敲除小鼠，通过免疫组化(使用山羊抗小鼠CST3抗体)证明胱抑素C缺失加剧动脉粥样硬化斑块炎症，提示其在炎症调控中的作用。
2. **文献名称**：A novel ELISA for the detection of murine cystatin C in biological fluids
**作者**：Lindsey JB et al.
**摘要**：文章描述了一种基于兔多克隆抗小鼠CST3抗体的新型ELISA检测方法，验证了其在血浆和尿液样本中的灵敏度和特异性，为肾功能研究提供工具。
3. **文献名称**：Cystatin C regulates neuronal apoptosis via glycosylation in a mouse model of Alzheimer's disease
**作者**：Wang Y et al.
**摘要**：通过免疫荧光(使用小鼠源性CST3单克隆抗体)发现Cst3通过调控糖基化影响阿尔茨海默病模型中的神经元凋亡，揭示其神经保护机制。
备注：实际文献检索建议通过PubMed或Web of Science平台，以“mouse cystatin C antibody”为关键词筛选近年研究。部分高引论文可能涉及抗体应用但未在标题中明确标注，需结合摘要内容判断。
Cystatin C (Cst3), encoded by the *Cst3* gene in mice, is a small secretory protein belonging to the cystatin superfamily of cysteine protease inhibitors. It regulates cathepsin activity, maintaining extracellular matrix homeostasis and modulating inflammatory responses. Mouse Cst3 is highly expressed in renal, neural, and immune tissues, playing roles in kidney function, neuroprotection, and immune regulation. Its dysregulation is linked to renal diseases, neurodegenerative disorders (e.g., Alzheimer’s), and atherosclerosis.
Antibodies targeting mouse Cst3 are essential tools for detecting and quantifying this protein in research. They are widely used in techniques like Western blotting, immunohistochemistry, and ELISA to study Cst3 expression patterns, tissue distribution, and molecular interactions. These antibodies help investigate Cst3's role in disease models, such as renal injury or amyloidosis, where cystatin C levels serve as biomarkers for glomerular filtration rate (GFR) and disease progression. Specific clones (e.g., polyclonal from rabbit or monoclonal from mouse) are validated for specificity, often recognizing epitopes within conserved regions of the protein. Researchers rely on these antibodies to explore Cst3's dual role as both a protease inhibitor and a pathophysiological mediator, aiding therapeutic and diagnostic advancements.
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