| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Suppressor of G2 allele of SKP1 homolog, Protein 40-6-3, Sgt1, SUGT1 |
| Entrez GeneID | 10910 |
| WB Predicted band size | 41.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SUGT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-356 amino acids from the C-terminal region of human SUGT1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于SUGT1抗体的虚拟参考文献(示例格式，实际文献需根据具体研究补充)：
1. **文献名称**：SUGT1 regulates mitochondrial dysfunction via ERK signaling in neurodegenerative diseases
**作者**：Chen L, et al.
**摘要**：本研究利用SUGT1特异性抗体，发现SUGT1蛋白在阿尔茨海默病患者脑组织中表达降低，并通过调控ERK信号通路影响线粒体功能，提示其作为神经退行性疾病治疗靶点的潜力。
2. **文献名称**：Development and validation of a novel SUGT1 monoclonal antibody for cancer biomarker studies
**作者**：Wang Y, et al.
**摘要**：文章报道了一种高特异性SUGT1单克隆抗体的开发，验证了其在结直肠癌组织中的高表达，并证实SUGT1通过Wnt/β-catenin通路促进肿瘤侵袭，可作为潜在癌症标志物。
3. **文献名称**：SUGT1 interacts with HSP90 in protein quality control: Insights from co-immunoprecipitation assays
**作者**：Smith J, et al.
**摘要**：通过SUGT1抗体进行免疫共沉淀实验，揭示了SUGT1与HSP90的相互作用机制，阐明其在细胞应激条件下维持蛋白质折叠稳态的关键作用。
注：以上文献为示例，实际引用需查询PubMed、Google Scholar等数据库获取真实研究。
SUGT1 (Suppressor of G2 allele of SKP1 homolog) is a conserved eukaryotic protein involved in protein quality control and chaperone-mediated processes. It functions as a co-chaperone, interacting with heat shock proteins (e.g., HSP90) to facilitate the folding and stabilization of client proteins. SUGT1 also plays a role in the assembly of the kinetochore complex during mitosis, ensuring chromosomal segregation fidelity. Additionally, it participates in the endoplasmic reticulum-associated degradation (ERAD) pathway by linking ubiquitinated substrates to the p97/VCP ATPase for proteasomal degradation. Dysregulation of SUGT1 has been implicated in cancer, neurodegenerative diseases, and developmental disorders.
SUGT1 antibodies are essential tools for studying its expression, localization, and molecular interactions. They enable detection via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Research using these antibodies has elucidated SUGT1’s dual roles in stress response and cell cycle regulation, as well as its potential as a biomarker or therapeutic target. Commercial SUGT1 antibodies are typically raised against specific epitopes in human or murine SUGT1. with validation in knockout models to ensure specificity. Ongoing studies focus on its involvement in disease mechanisms and protein homeostasis networks.
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