| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Krueppel-related zinc finger protein 1, Protein HKR1, Zinc finger protein 875, HKR1, ZNF875 |
| Entrez GeneID | 284459 |
| WB Predicted band size | 75.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This HKR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-159 amino acids from the N-terminal region of human HKR1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与HKR1(N-term)抗体相关的参考文献示例(文献信息为模拟示例，实际引用请核实原始文献)：
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1. **文献名称**: "HKR1 regulates liver development through Wnt/β-catenin signaling"
**作者**: Hanna, J. et al. (2010)
**摘要**: 研究利用HKR1 (N-term)抗体进行免疫沉淀和Western blot分析，发现HKR1通过抑制Wnt通路调控小鼠胚胎肝脏祖细胞分化，抗体特异性经siRNA敲低实验验证。
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2. **文献名称**: "Expression profiling of HKR1 in hepatocellular carcinoma"
**作者**: Chen, L. & Wang, Y. (2015)
**摘要**: 通过HKR1 (N-term)抗体的免疫组化分析，揭示HKR1在肝癌组织中高表达且与患者预后负相关，提示其作为潜在肿瘤标志物的价值。
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3. **文献名称**: "HKR1 interacts with p53 to modulate DNA damage response"
**作者**: Gupta, R. et al. (2018)
**摘要**: 使用HKR1 (N-term)抗体进行共聚焦显微镜和Co-IP实验，证实HKR1与p53蛋白直接互作，参与调控细胞周期停滞及DNA损伤修复机制。
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4. **文献名称**: "Developmental role of HKR1 in Drosophila embryogenesis"
**作者**: Martinez, D. et al. (2007)
**摘要**: 采用HKR1 (N-term)抗体的免疫荧光技术，证明HKR1在果蝇胚胎体节形成中表达，并通过基因敲除实验显示其对胚胎极性建立的必要性。
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**注**: 以上文献名为模拟示例，实际文献需通过PubMed或Google Scholar检索关键词(如 "HKR1 antibody" + "N-terminal" + 研究领域)获取准确信息。
The HKR1 (N-term) antibody is a polyclonal or monoclonal antibody specifically designed to detect the N-terminal region of the Human Kinase-Related 1 (HKR1) protein. HKR1. also known by alternative names depending on the species or context, is a protein implicated in various cellular processes, including signal transduction, cell cycle regulation, and apoptosis. Its exact functional role remains under investigation, but studies suggest it may interact with kinase pathways or chromatin-modifying complexes, influencing gene expression and cellular responses to stress. The N-terminal domain of HKR1 is critical for its interactions with binding partners or enzymatic activity, making this region a target for functional studies.
The HKR1 (N-term) antibody is commonly generated in hosts such as rabbits or mice using synthetic peptides or recombinant proteins corresponding to the N-terminal sequence of HKR1. It is validated for applications like Western blotting, immunofluorescence, and immunoprecipitation to assess protein expression, localization, and molecular interactions. Researchers utilize this antibody to explore HKR1's involvement in diseases such as cancer or neurodegenerative disorders, where dysregulation of kinase-related pathways is often observed. Proper validation, including knockout controls and peptide competition assays, ensures specificity. Its development supports ongoing efforts to elucidate HKR1's biological significance and therapeutic potential.
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