首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal AKR1E2 Antibody

  • 中文名: AKR1E2抗体
  • 别    名: 5-anhydro-D-fructose reductase, AF reductase, Aldo-keto reductase family 1 member C-like protein 2, Aldo-keto reductase family 1 member E2, LoopADR, Testis-specific protein, hTSP, AKR1E2, AKR1CL2, AKRDC1
货号: IPDX32038
Price: ¥1180
数量:
大包装询价

验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Aliases5-anhydro-D-fructose reductase, AF reductase, Aldo-keto reductase family 1 member C-like protein 2, Aldo-keto reductase family 1 member E2, LoopADR, Testis-specific protein, hTSP, AKR1E2, AKR1CL2, AKRDC1
Entrez GeneID83592
WB Predicted band size36.6kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis AKR1E2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 291-320 amino acids from the C-terminal region of human AKR1E2.
FormulationPurified antibody in PBS with 0.05% sodium azide.

+ +

参考文献

以下是关于AKR1E2抗体的3篇参考文献示例(注:以下信息为模拟示例,具体文献需根据实际数据库检索验证):

---

1. **文献名称**: *"Characterization of AKR1E2 as a Novel Aldo-Keto Reductase Involved in Detoxification Processes"*

**作者**: Smith JL, et al.

**摘要**: 本研究通过重组表达人源AKR1E2蛋白并制备多克隆抗体,验证了其在肝脏和肾脏组织中的特异性表达。抗体经Western blot和免疫组化验证,证实AKR1E2在氧化应激反应中参与内源性羰基化合物的代谢。

2. **文献名称**: *"AKR1E2 Antibody Development and Its Application in Neurodegenerative Disease Models"*

**作者**: Tanaka K, et al.

**摘要**: 研究团队开发了高特异性AKR1E2单克隆抗体,用于检测阿尔茨海默病模型小鼠脑组织中的酶表达变化。结果显示AKR1E2可能通过调节神经毒性醛类物质的积累影响疾病进展。

3. **文献名称**: *"Tissue-Specific Expression Profiling of AKR1E2 Using Polyclonal Antibodies"*

**作者**: Chen R, et al.

**摘要**: 利用兔源多克隆抗体对AKR1E2进行组织分布分析,发现其在胃肠道和睾丸中高表达,提示其可能参与激素代谢或黏膜保护功能。抗体特异性通过siRNA敲低实验验证。

---

建议通过PubMed或Google Scholar以关键词“AKR1E2 antibody”、“AKR1E2 immunohistochemistry”等检索最新文献以获取准确信息。部分研究可能需结合AKR1家族(如AKR1C/AKR1B)抗体的交叉应用文献。

背景信息

The AKR1E2 antibody is designed to target the aldo-keto reductase family 1 member E2 (AKR1E2), an enzyme belonging to the AKR superfamily involved in metabolic and detoxification processes. AKR1E2 is implicated in the reduction of ketones, aldehydes, and steroid intermediates, playing roles in cellular protection against oxidative stress and xenobiotic metabolism. Although less characterized than other AKR members like AKR1C or AKR1B isoforms, AKR1E2 is thought to contribute to pathways regulating steroid hormone biosynthesis and reactive carbonyl scavenging. Research on AKR1E2 antibodies has focused on elucidating its expression patterns, substrate specificity, and physiological relevance. These antibodies are utilized in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to study AKR1E2 localization in tissues like the liver, kidney, and brain. Emerging studies suggest potential links between AKR1E2 dysregulation and diseases, including cancer and metabolic disorders, though its exact pathophysiological roles remain under investigation. The development of AKR1E2-specific antibodies aids in exploring its enzymatic activity, regulatory mechanisms, and potential as a biomarker or therapeutic target in oxidative stress-related conditions.

客户数据及评论

折叠内容

大包装询价

×