| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Alpha-parvin, Actopaxin, Parva, Actp |
| Entrez GeneID | 57342 |
| WB Predicted band size | 42.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This Mouse Parva antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-93 amino acids from the N-terminal region of mouse Parva. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Mouse Parva(N-term)抗体的3篇参考文献示例(注：Parva为细胞骨架相关蛋白，以下为模拟文献，实际文献需根据具体研究补充)：
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1. **文献名称**: *"Parva regulates focal adhesion dynamics through its N-terminal domain in mouse fibroblasts"*
**作者**: Smith J, et al.
**摘要**: 本研究利用针对Parva蛋白N端的特异性抗体，通过免疫荧光和免疫印迹分析，揭示了Parva通过其N端结构域调控小鼠成纤维细胞黏着斑的形成与分解，影响细胞迁移能力。
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2. **文献名称**: *"Characterization of a novel monoclonal antibody targeting the N-terminal region of murine Parva"*
**作者**: Lee H, et al.
**摘要**: 文章报道了一种针对小鼠Parva蛋白N端表位的高特异性单克隆抗体的开发与验证。该抗体在Western blot及免疫共沉淀实验中表现优异，适用于研究Parva在组织分布中的表达差异。
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3. **文献名称**: *"Role of Parva in cardiomyocyte adhesion: Insights from N-terminal antibody-based inhibition assays"*
**作者**: Gonzalez R, et al.
**摘要**: 通过使用Parva N端抗体阻断其功能，研究发现Parva的N端结构域对心肌细胞黏附及机械应力响应至关重要，为心血管疾病机制提供了新视角。
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**备注**：以上为示例文献，实际引用需通过PubMed或Web of Science等平台检索真实文献(关键词：Parva antibody N-terminal, mouse)。若研究较为小众，建议查阅抗体供应商(如Santa Cruz、Abcam)提供的产品引用文献。
The Mouse Parva (N-term) antibody is designed to detect the N-terminal region of parvin alpha (α-parvin), a protein encoded by the PARVA gene in mice. α-parvin belongs to the parvin family of actin-binding proteins, which play critical roles in cell adhesion, migration, and cytoskeletal organization. It interacts with integrin-linked kinase (ILK) and paxillin to form the IPP complex, linking integrin-mediated extracellular matrix signals to intracellular actin dynamics. This interaction is essential for maintaining focal adhesion stability and regulating cell shape changes during processes like embryogenesis, wound healing, and immune response.
The antibody is commonly used in research to study α-parvin's involvement in cellular mechanotransduction and its implications in diseases such as cancer, cardiovascular disorders, and muscular dystrophies. By targeting the N-terminal domain, it specifically recognizes full-length α-parvin while avoiding cross-reactivity with other parvin isoforms (β-parvin and γ-parvin). Validated applications include Western blotting, immunofluorescence, and immunohistochemistry, often in studies using mouse-derived cell lines or tissue samples. Researchers rely on this antibody to explore α-parvin's regulatory functions in PI3K/AKT and Rho GTPase signaling pathways, as well as its role in apoptosis resistance and epithelial-mesenchymal transition (EMT) in metastatic cancers. Proper validation with knockout controls is recommended to ensure specificity in experimental settings.
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