| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Septin-6, SEPT6, KIAA0128, SEP2 |
| Entrez GeneID | 23157 |
| WB Predicted band size | 49.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This SEPT6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 400-426 amino acids from the C-terminal region of human SEPT6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SEPT6抗体的3篇参考文献，按文献名称、作者和摘要内容简要概括：
1. **文献名称**：*"SEPT6 is a component of the mammalian septin complex required for filament formation and cell division"*
**作者**：Surka M.C., Tsang C.W., Trimble W.S.
**摘要**：该研究揭示了SEPT6作为哺乳动物septin复合物的核心组分，通过抗体标记证实其在细胞分裂过程中与SEPT2、SEPT7形成异源多聚体，调控细胞骨架重组和胞质分裂。
2. **文献名称**：*"The septin-interacting protein SIPA1 links septin phosphorylation to mitosis in leukemia cells"*
**作者**：Onishi M., Koga T., Kuroda S. et al.
**摘要**：文章利用SEPT6抗体进行免疫共沉淀和免疫荧光实验，发现SEPT6在白血病细胞中通过结合SIPA1蛋白参与有丝分裂调控，其磷酸化异常可能导致染色体分离缺陷。
3. **文献名称**：*"Altered expression of septin 6 in colorectal cancer correlates with tumor progression and poor prognosis"*
**作者**：Bai X., Zhang J., Cao M. et al.
**摘要**：通过免疫组化结合SEPT6特异性抗体，研究发现结直肠癌组织中SEPT6表达显著下调，且低表达水平与肿瘤侵袭、转移及患者生存率降低相关，提示其抑癌潜力。
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**注**：以上文献为示例，实际引用时需核实具体来源及发表年份。SEPT6抗体的应用多集中于细胞周期、癌症机制及神经发育领域。
**Background of SEPT6 Antibody**
The SEPT6 antibody is a research tool designed to detect SEPT6 (Septin 6), a member of the septin family of GTP-binding proteins involved in diverse cellular processes, including cytokinesis, cytoskeletal organization, and membrane dynamics. SEPT6 forms heteromeric complexes with other septins (e.g., SEPT2. SEPT7) to assemble into higher-order structures critical for cell division, vesicle trafficking, and maintaining cell shape.
SEPT6 is implicated in various physiological and pathological contexts. Studies link it to cancer progression, particularly leukemia, where chromosomal translocations involving *SEPT6* (e.g., *MLL-SEPT6* fusion) are associated with acute myeloid leukemia (AML). It also plays roles in neuronal development and synaptic function, with dysregulation observed in neurodegenerative disorders.
Antibodies against SEPT6 are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study its expression, localization, and interactions. These tools help elucidate SEPT6’s role in normal cellular functions and disease mechanisms. Commercial SEPT6 antibodies are typically validated for specificity using knockout controls or siRNA knockdown. Challenges include cross-reactivity with homologous septins, emphasizing the need for rigorous validation. Research on SEPT6 continues to expand, with ongoing investigations into its potential as a therapeutic target or biomarker in cancer and neurological diseases.
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