| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Polycystic kidney disease 2-like 2 protein, Polycystin-2L2, Polycystin-L2, PKD2L2 |
| Entrez GeneID | 27039 |
| WB Predicted band size | 73.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PKD2L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 193-219 amino acids from the Central region of human PKD2L2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PKD2L2抗体的3篇参考文献示例(文献信息为模拟内容，实际文献需根据数据库查询验证)：
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1. **文献名称**: "Characterization of PKD2L2 as a novel ion channel in human tissues"
**作者**: Smith A, et al.
**摘要**: 本研究利用特异性PKD2L2抗体，通过免疫组织化学和Western blot技术，揭示了PKD2L2蛋白在肾脏和肠道中的广泛表达。结果显示其可能参与细胞钙离子调控，为多囊肾病机制研究提供新方向。
2. **文献名称**: "PKD2L2 antibody validation in murine models of cystic diseases"
**作者**: Tanaka K, et al.
**摘要**: 文章报道了一种高亲和力PKD2L2单克隆抗体的开发，并在小鼠模型中验证其特异性。该抗体成功用于流式细胞术检测，证明PKD2L2在肾囊肿形成早期阶段的表达上调。
3. **文献名称**: "Interactions between PKD2L2 and mTOR signaling pathways in cancer progression"
**作者**: Chen L, et al.
**摘要**: 通过免疫共沉淀(使用PKD2L2抗体)和基因沉默实验，研究发现PKD2L2与mTOR通路存在功能关联，可能影响肿瘤细胞的增殖和迁移能力，提示其作为癌症治疗靶点的潜力。
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**注意**：以上文献为示例，实际研究中请通过PubMed或Web of Science等平台以“PKD2L2 antibody”或“PKD2L2 protein”为关键词检索最新文章。若研究较少，可扩展至“polycystin family antibodies”或相关信号通路文献。
The PKD2L2 (Polycystic Kidney Disease 2-Like 2) protein, also known as TRPP3. belongs to the transient receptor potential (TRP) channel family and the polycystin subfamily. It is a calcium-permeable non-selective cation channel characterized by six transmembrane domains. While its exact physiological roles remain under investigation, PKD2L2 is implicated in cellular processes such as calcium signaling, mechanosensation, and acid-sensing. It is expressed in diverse tissues, including the gastrointestinal tract, kidney, testis, and certain neurons, with studies suggesting potential involvement in pH-dependent taste signaling and renal function. Aberrant PKD2L2 expression has been observed in cancers, particularly prostate and colorectal cancers, linking it to tumor progression pathways.
PKD2L2 antibodies are critical tools for studying the protein's localization, expression patterns, and molecular interactions. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate its roles in health and disease. Commercial antibodies target specific epitopes, often in the N- or C-terminal regions. However, challenges persist in ensuring antibody specificity due to structural similarities with related polycystin family members (e.g., PKD2L1). Recent research leverages these antibodies to explore PKD2L2's potential as a therapeutic target, particularly in oncology, while basic studies continue to elucidate its fundamental biological functions and regulation mechanisms. Validation using knockout controls remains essential for reliable experimental outcomes.
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