| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Chymotrypsin-like protease CTRL-1, 3421-, CTRL, CTRL1 |
| Entrez GeneID | 1506 |
| WB Predicted band size | 28.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CTRL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 72-98 amino acids from the Central region of human CTRL. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CTRL抗体的参考文献示例(注：以下文献为示例性质，具体内容可能需要根据实际研究调整)：
1. **文献名称**：**"Development of a High-Affinity Anti-CTRL Monoclonal Antibody for Functional Studies in Neuroendocrine Cells"**
**作者**：Zhang Y, et al.
**摘要**：本研究报道了一种针对CTRL(胆囊收缩素受体样蛋白)的高亲和力单克隆抗体的开发，验证了其在神经内分泌细胞中的特异性结合能力，并证明其可抑制受体介导的细胞内钙信号传导，为相关疾病机制研究提供工具。
2. **文献名称**：**"CTRL-Specific Antibody Therapy Attenuates Tumor Growth in Colorectal Cancer Models"**
**作者**：Smith JL, et al.
**摘要**：通过体内外实验，该研究证明抗CTRL抗体通过阻断肿瘤微环境中的配体-受体相互作用，显著抑制结直肠癌细胞的增殖和转移，提示其作为靶向治疗的潜力。
3. **文献名称**：**"Structural and Functional Characterization of CTRL Antibodies for Diagnostic Applications"**
**作者**：Kim H, et al.
**摘要**：解析了CTRL抗体与抗原表位的结合模式，开发了一种基于该抗体的ELISA检测方法，用于临床样本中CTRL蛋白的定量分析，提高了胰腺疾病诊断的灵敏度。
4. **文献名称**：**"Anti-CTRL Antibody Modulates Immune Response in Autoimmune Hepatitis"**
**作者**：Garcia R, et al.
**摘要**：在小鼠自身免疫性肝炎模型中，抗CTRL抗体通过调节T细胞活化和细胞因子释放，显著减轻肝脏炎症，为免疫相关疾病的治疗提供新策略。
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**说明**：
- 上述文献为示例，实际研究中需根据具体靶点(如CTRL是否为胆囊收缩素受体、酶或其他蛋白)调整内容。
- 建议通过PubMed或Google Scholar以关键词“CTRL antibody”、“Cholecystokinin receptor antibody”等检索最新文献。
CTRL antibody targets chymotrypsin-like protease (CTRL), a serine protease involved in regulating protein catabolism and cellular homeostasis. Initially identified for its role in degrading damaged or misfolded proteins within lysosomes, CTRL is part of the proteolytic system that maintains cellular quality control. It is structurally related to chymotrypsin and functions by cleaving peptide bonds at specific hydrophobic residues. Dysregulation of CTRL activity has been linked to pathologies such as cancer, neurodegenerative diseases, and inflammatory disorders, where impaired proteostasis contributes to disease progression.
CTRL antibodies are primarily used in research to study protease expression, localization, and activity in various tissues. They enable detection of CTRL via techniques like Western blotting, immunohistochemistry, and immunofluorescence. In therapeutic contexts, modulating CTRL activity is explored for conditions like amyloidosis or cancers characterized by abnormal protein aggregation. Recent studies also highlight its potential role in immune regulation, as CTRL influences cytokine processing and antigen presentation. However, the exact mechanisms remain under investigation, emphasizing the need for high-specificity CTRL antibodies to advance both basic and translational research in proteostasis networks.
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