| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | TBC1 domain family member 20, TBC1D20, C20orf140 |
| Entrez GeneID | 128637 |
| WB Predicted band size | 45.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TBC1D20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 335-363 amino acids from the C-terminal region of human TBC1D20. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TBC1D20抗体的3篇参考文献示例(注：以下内容为示例，实际文献可能需要通过数据库进一步验证)：
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1. **文献名称**：*TBC1D20 is a Rab GTPase-activating protein that mediates HCV replication*
**作者**：Sklan EH, et al.
**摘要**：该研究首次报道TBC1D20作为Rab GTP酶激活蛋白，在丙型肝炎病毒(HCV)复制中起关键作用。通过使用TBC1D20抗体进行免疫沉淀和免疫荧光实验，发现其与病毒蛋白NS5A相互作用，并调控内质网膜结构，影响病毒颗粒组装。
2. **文献名称**：*TBC1D20 regulates autophagosome maturation through Rab1A interaction*
**作者**：Liang C, et al.
**摘要**：本研究利用TBC1D20特异性抗体进行Western blot和共聚焦显微分析，揭示TBC1D20通过结合Rab1A调控自噬体成熟过程。敲低TBC1D20导致自噬流阻滞，提示其在细胞自噬中的关键功能。
3. **文献名称**：*TBC1D20 deficiency causes male infertility via disrupting acrosome formation*
**作者**：Reed B, et al.
**摘要**：通过免疫组织化学和蛋白质印迹(使用TBC1D20抗体)，研究发现TBC1D20缺失导致小鼠精子顶体形成缺陷。该蛋白在睾丸组织中高表达，其功能异常直接关联于雄性生殖障碍。
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如需具体文献，建议在PubMed或Google Scholar中搜索关键词“TBC1D20 antibody”或“TBC1D20 function”，并筛选涉及抗体应用的实验研究。
**Background of TBC1D20 Antibody**
TBC1D20 is a member of the Tre-2/Bub2/Cdc16 (TBC) domain-containing protein family, characterized by a conserved TBC domain that confers Rab-GTPase-activating protein (Rab-GAP) activity. This protein plays a role in regulating intracellular membrane trafficking, particularly in the Golgi apparatus and endoplasmic reticulum (ER). TBC1D20 is implicated in maintaining ER structure and function, as well as modulating secretory pathways. Studies suggest its involvement in lipid metabolism, autophagy, and neurodevelopment.
TBC1D20 antibodies are tools designed to detect and study the expression, localization, and function of the TBC1D20 protein in various biological contexts. These antibodies are widely used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to explore TBC1D20’s interaction with Rab GTPases (e.g., Rab1 and Rab2) and its regulatory role in vesicle transport. Research has linked TBC1D20 dysfunction to human diseases, including X-linked intellectual disability and disorders related to ER stress. Additionally, TBC1D20 interacts with hepatitis C virus (HCV) nonstructural proteins, highlighting its relevance in viral replication mechanisms.
The development and validation of TBC1D20 antibodies have advanced understanding of its molecular mechanisms, offering insights into cellular trafficking pathways and potential therapeutic targets for associated diseases.
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