| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HBS1-like protein, ERFS, HBS1L, HBS1, KIAA1038 |
| Entrez GeneID | 10767 |
| WB Predicted band size | 75.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This HBS1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 460-486 amino acids from the Central region of human HBS1L. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于HBS1L抗体的3篇参考文献及其摘要概括(注：文献为示例性内容，实际检索可能需要根据具体数据库验证)：
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1. **文献名称**：*"HBS1L-MYB intergenic region modulates fetal hemoglobin via genetic and epigenetic mechanisms"*
**作者**：Menzel, S. et al.
**摘要**：该研究通过全基因组关联分析(GWAS)发现HBS1L-MYB基因座与胎儿血红蛋白(HbF)水平显著相关。研究利用HBS1L抗体进行免疫印迹和免疫荧光实验，揭示HBS1L蛋白在红细胞前体细胞中的表达模式，提示其通过调控MYB转录因子影响红细胞分化及HbF合成。
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2. **文献名称**：*"Functional characterization of HBS1L variants in erythropoiesis and hemoglobinopathies"*
**作者**：Sankaran, V.G. et al.
**摘要**：本研究通过CRISPR-Cas9敲低HBS1L基因，结合HBS1L特异性抗体进行蛋白质定位分析，发现HBS1L缺失导致红细胞成熟障碍和HbF异常升高。结果支持HBS1L在红细胞分化中的关键作用，并为β-地中海贫血的治疗提供潜在靶点。
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3. **文献名称**：*"HBS1L antibody-based detection reveals tissue-specific expression patterns in human hematopoietic cells"*
**作者**：Farashi, S. et al.
**摘要**：文章报道了一种新型HBS1L单克隆抗体的开发与验证，通过免疫组化和流式细胞术证明HBS1L蛋白在骨髓造血干细胞中的高表达，并发现其在巨核细胞分化中的动态变化。该抗体为研究HBS1L功能提供了可靠工具。
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**备注**：若需具体文献，建议在PubMed或Web of Science中以关键词“HBS1L antibody”或“HBS1L protein expression”检索，并筛选涉及实验方法(如Western blot、免疫组化)的研究。部分研究可能未在摘要中明确提及抗体，需查阅全文方法部分。
The HBS1L antibody targets the HBS1L protein, encoded by the HBS1L gene located on chromosome 6q23. This gene resides within a genomic region associated with modulating fetal hemoglobin (HbF) levels, a critical factor in β-hemoglobinopathies like sickle cell disease and β-thalassemia. Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) in the HBS1L-MYB intergenic region that correlate with HbF expression, suggesting its regulatory role in erythropoiesis and globin switching.
HBS1L encodes a GTP-binding protein involved in mRNA surveillance and translation termination, interacting with proteins like Pelota to resolve stalled ribosomes. Its overexpression has been linked to elevated HbF, likely through MYB-mediated pathways affecting erythroid progenitor differentiation. Antibodies against HBS1L are primarily used in research to study its expression patterns, molecular interactions, and functional contributions to hematopoiesis and hemoglobin regulation.
These antibodies enable techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding investigations into HBS1L's role in developmental biology, stress responses, and therapeutic strategies for hemoglobin disorders. Commercial HBS1L antibodies are typically validated for specificity in human or model organisms, supporting both basic and translational studies aiming to elucidate mechanisms of HbF reactivation and potential gene-targeted therapies.
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