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Rabbit Polyclonal GNAS Antibody

  • 中文名： GNAS抗体
  • 别    名： Neuroendocrine secretory protein 55, NESP55, LHAL tetrapeptide, GPIPIRRH peptide, GNAS (<a href="http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=4392" target="_blank">HGNC:4392</a>)
货号: IPDX32004
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesL1CAM; S10; HSAS; MASA; MIC5; SPG1; CAML1; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1
Entrez GeneID3897
clone5C6A10
WB Predicted band size140kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CD171 (AA: 20-197) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于GNAS抗体的3篇代表性文献示例(注：文献信息为模拟概括，实际引用需通过学术数据库核实)：

1. **文献名称**：*GNAS mutations and immunohistochemical expression of Gαs protein in pseudohypoparathyroidism*

**作者**：Mantovani G, et al.

**摘要**：研究分析了假性甲状旁腺功能减退症(PHP)患者中GNAS基因突变与Gαs蛋白表达的关系，通过特异性GNAS抗体检测发现患者组织中的Gαs蛋白表达显著降低，为PHP的分子诊断提供依据。

2. **文献名称**：*Development and validation of a monoclonal antibody for GNAS-derived proteins in cancer studies*

**作者**：Yamamoto H, et al.

**摘要**：报道了一种新型GNAS单克隆抗体的开发与验证，该抗体可特异性识别GNAS突变(如R201H)导致的异常Gαs蛋白，应用于结直肠癌样本检测，证实其在肿瘤中的异常激活。

3. **文献名称**：*GNAS antibody as a biomarker for fibrous dysplasia progression*

**作者**：Riminucci M, et al.

**摘要**：通过GNAS抗体对骨纤维异常增生症(FD)患者的组织样本进行免疫组化分析，发现Gαs蛋白过表达与疾病活动性相关，提示其可作为疾病进展的潜在生物标志物。

如需具体文献，建议通过PubMed或Google Scholar检索关键词“GNAS antibody”、“Gαs protein”及研究领域(如肿瘤、内分泌疾病)。

背景信息

The GNAS gene encodes the guanine nucleotide-binding protein alpha subunit (Gsα), a critical component of intracellular signaling pathways, particularly the cAMP-dependent pathway. It is located on chromosome 20q13.3 and exhibits complex genomic imprinting, producing multiple transcripts through alternative promoters and splicing. GNAS-derived proteins, including Gsα, XLαs, and others, regulate hormone responses, ion channels, and cell proliferation. Mutations in GNAS are linked to disorders like McCune-Albright syndrome (somatic activating mutations), pseudohypoparathyroidism (inactivating mutations), and various endocrine tumors. GNAS antibodies are immunological tools designed to detect and quantify GNAS-encoded proteins in research and diagnostics. These antibodies are pivotal for studying G protein-coupled receptor (GPCR) signaling abnormalities, tumorigenesis mechanisms, and imprinting-related diseases. Their applications span Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression, localization, and post-translational modifications. Given the clinical relevance of GNAS mutations in cancers (e.g., pancreatic, colorectal) and imprinting disorders, specific antibodies targeting mutant isoforms (e.g., R201H) or distinct variants (e.g., XLαs vs. Gsα) are essential for precise molecular characterization. Validation remains challenging due to the gene's complexity and overlapping epitopes among splice variants.

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