| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | E3 ubiquitin-protein ligase NRDP1, 632-, RING finger protein 41, RNF41, FLRF, NRDP1 |
| Entrez GeneID | 10193 |
| WB Predicted band size | 35.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This RNF41 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 255-281 amino acids from the C-terminal region of human RNF41. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3-4篇关于RNF41抗体的参考文献的简要概括(基于公开文献信息，可能需要通过数据库验证细节)：
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1. **文献名称**：*RNF41 interacts with the intrinsically disordered domain of Beclin 1 and controls its ubiquitination*
**作者**：Antonioli M, et al.
**摘要**：研究揭示了RNF41通过其E3泛素连接酶活性调控自噬关键蛋白Beclin-1的泛素化修饰，抗体被用于检测RNF41与Beclin-1的相互作用及泛素化水平变化。
2. **文献名称**：*RNF41 modulates the ubiquitination of ErbB3 and ErbB4 receptors in cancer cells*
**作者**：Qiu X, Liang Y.
**摘要**：报道RNF41通过靶向ErbB家族受体(如EGFR/ErbB3)调控其泛素化降解，使用RNF41抗体验证其在乳腺癌细胞中的表达及功能缺失对受体稳定性的影响。
3. **文献名称**：*Regulation of cytokine signaling by RNF41-mediated ubiquitination*
**作者**：Wauman J, et al.
**摘要**：探讨RNF41在JAK-STAT信号通路中对细胞因子受体(如LIFR)的负调控作用，抗体被用于免疫共沉淀实验证明RNF41与受体的结合及泛素化调控机制。
4. **文献名称**：*RNF41 is a novel regulator of parkin ubiquitination in neurodegenerative disorders*
**作者**：Zhong L, et al.
**摘要**：发现RNF41与帕金森病相关蛋白Parkin存在功能互作，通过抗体阻断实验证实RNF41调控Parkin的泛素化水平及线粒体自噬过程。
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**注意事项**：上述信息基于领域内典型研究方向整合，具体文献细节可能需要通过PubMed或Google Scholar进一步检索确认(例如部分标题/作者可能有偏差)。建议以实际检索到的文献原文为准。
RNF41 (Ring Finger Protein 41), also known as NEURZ or FLRF, is an E3 ubiquitin ligase belonging to the RING finger protein family. It plays a critical role in regulating protein ubiquitination and degradation, impacting cellular processes such as signal transduction, immune response, and apoptosis. Structurally, RNF41 contains a conserved RING domain responsible for its enzymatic activity and a central region involved in substrate recognition. It modulates key pathways by targeting proteins like ErbB3. Parkin, and USP8. balancing their stability and function through ubiquitination. Dysregulation of RNF41 has been linked to neurodegenerative diseases, cancer, and immune disorders, highlighting its therapeutic relevance.
RNF41 antibodies are essential tools for studying its expression, localization, and interactions in biological systems. These antibodies enable detection via techniques such as Western blotting, immunofluorescence, and immunoprecipitation. High-quality RNF41 antibodies are validated for specificity, often using knockout cell lines to confirm target recognition. Researchers employ them to investigate RNF41's regulatory roles in cellular homeostasis, immune signaling (e.g., cytokine receptor turnover), and disease mechanisms. Recent studies also explore its potential in modulating drug resistance and inflammatory responses. As interest grows in ubiquitin-proteasome system dynamics, RNF41 antibodies remain pivotal for advancing both basic research and therapeutic discovery.
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