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Rabbit Polyclonal PDE4C(N-term) Antibody

  • 中文名： PDE4C (N-term)抗体
  • 别    名： cAMP-specific 3',5'-cyclic phosphodiesterase 4C, DPDE1, PDE21, PDE4C, DPDE1
货号: IPDX32002
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasescAMP-specific 3',5'-cyclic phosphodiesterase 4C, DPDE1, PDE21, PDE4C, DPDE1
Entrez GeneID5143
WB Predicted band size79.9kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis PDE4C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 5-31 amino acids from the N-terminal region of human PDE4C.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于PDE4C(N-term)抗体的参考文献示例(注：部分内容为模拟，建议通过学术数据库核实最新文献)：

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1. **文献名称**：*Characterization of PDE4C Isoforms and Antibody Specificity in Human Tissues*

**作者**：Smith A, et al.

**摘要**：该研究开发了针对PDE4C N端的多克隆抗体，验证了其在人脑和心脏组织中的特异性。通过Western blot和免疫组化发现，PDE4C在神经元和心肌细胞中高表达，提示其可能参与cAMP信号调控。

2. **文献名称**：*Role of PDE4C in cAMP Signaling: Insights from Knockout Mice and Antibody-Based Profiling*

**作者**：Jones R, et al.

**摘要**：利用PDE4C N-term抗体分析基因敲除小鼠模型，发现PDE4C缺失导致海马体cAMP水平升高，影响学习记忆功能。抗体特异性通过siRNA敲低实验验证。

3. **文献名称**：*PDE4C Expression in Cancer: A Comparative Study Using N-terminal Specific Antibodies*

**作者**：Lee H, et al.

**摘要**：比较多种PDE4亚型抗体在肿瘤组织中的应用，发现PDE4C N-term抗体在乳腺癌中特异性识别高迁移率条带，可能与肿瘤微环境中的异常剪接相关。

4. **文献名称**：*Development of Monoclonal Antibodies Targeting PDE4C for Pharmacological Studies*

**作者**：Zhang Y, et al.

**摘要**：报道了一种抗PDE4C N端的单克隆抗体的开发，用于筛选小分子抑制剂。该抗体在HEK293细胞过表达模型中显示出高亲和力，并成功应用于高通量药物筛选。

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**建议**：以上文献为示例性质，具体研究请通过PubMed或Google Scholar以关键词“PDE4C antibody N-term”或“PDE4C epitope mapping”检索，并结合最新研究进行补充。

背景信息

The PDE4C (N-term) antibody targets the N-terminal region of phosphodiesterase 4C (PDE4C), a member of the cyclic nucleotide phosphodiesterase (PDE) family. PDEs regulate intracellular signaling by hydrolyzing cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), modulating downstream pathways. PDE4C specifically degrades cAMP, influencing processes like inflammation, neuronal signaling, and cardiac function. The PDE4 subfamily (PDE4A-D) shares structural homology but differs in tissue distribution and regulatory roles. PDE4C is expressed in tissues such as the brain, heart, and immune cells, playing a role in cAMP-dependent signaling cascades. Antibodies against the N-terminal region are designed to detect PDE4C isoforms originating from distinct transcriptional start sites or splice variants, aiding in isoform-specific studies. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate PDE4C expression, localization, and function in physiological or pathological contexts, including neurological disorders, cardiovascular diseases, and immune dysregulation. Validation often involves knockout controls or peptide blocking to confirm specificity. Researchers utilize PDE4C (N-term) antibodies to explore its regulatory mechanisms, therapeutic potential, or interactions with signaling partners, contributing to drug discovery efforts targeting PDE4 enzymes for conditions like asthma, depression, or cognitive impairment.

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