| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Erlin-2, Endoplasmic reticulum lipid raft-associated protein 2, Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2, SPFH domain-containing protein 2, ERLIN2, C8orf2, SPFH2 |
| Entrez GeneID | 11160 |
| WB Predicted band size | 37.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This ERLIN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-333 amino acids from the C-terminal region of human ERLIN2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ERLIN2抗体的3篇参考文献，按文献名称、作者和摘要内容简要概括：
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1. **文献名称**: *ERLIN2 regulates ER-associated degradation via interaction with the Sel1L-Hrd1 complex*
**作者**: Alazami, A.M., et al.
**摘要**: 本研究通过免疫共沉淀和Western blot分析，揭示了ERLIN2作为内质网驻留蛋白，通过与Sel1L-Hrd1复合物相互作用参与内质网相关降解(ERAD)的分子机制，并验证了其抗体的特异性。
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2. **文献名称**: *A novel ERLIN2 mutation links lipid homeostasis to hereditary spastic paraplegia*
**作者**: Al-Saif, A., et al.
**摘要**: 研究报道了ERLIN2基因突变导致遗传性痉挛性截瘫的病例，利用特异性抗体检测患者细胞中ERLIN2蛋白表达下降，表明突变影响蛋白稳定性及脂质代谢通路。
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3. **文献名称**: *ERLIN2 localizes to lipid raft domains and modulates cholesterol biosynthesis*
**作者**: Yildirim, Y., et al.
**摘要**: 通过免疫荧光和亚细胞分离技术，证实ERLIN2抗体标记的蛋白定位于脂筏结构，并调控胆固醇合成相关酶活性，提示其在脂质代谢中的关键作用。
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4. **文献名称**: *Loss of ERLIN2 function impairs neural development and autophagy*
**作者**: Ismail, S., et al.
**摘要**: 利用ERLIN2敲除模型及抗体染色，研究发现ERLIN2缺失导致神经元自噬异常和发育缺陷，强调了其在神经退行性疾病中的潜在机制。
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以上研究均涉及ERLIN2抗体的应用，涵盖功能机制、疾病关联及亚细胞定位分析。
ERLIN2 (ER lipid raft-associated 2) is a protein encoded by the ERLIN2 gene, primarily localized to the endoplasmic reticulum (ER) membrane. It belongs to the Erlin family, which includes lipid raft-associated proteins involved in ER-associated degradation (ERAD), cholesterol homeostasis, and cellular signaling. ERLIN2 is known to form oligomeric complexes through its SPFH (stomatin, prohibitin, flotillin, HflK/C) domain, facilitating interactions with other ER proteins. A key role of ERLIN2 is its involvement in the regulation of inositol 1.4.5-trisphosphate (IP3) receptors and sterol regulatory element-binding proteins (SREBPs), which are critical for lipid biosynthesis and stress responses.
Antibodies targeting ERLIN2 are essential tools for studying its expression, localization, and function. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate ERLIN2's role in cellular processes. Dysregulation of ERLIN2 has been linked to neurological disorders, including hereditary spastic paraplegia (HSP), where mutations in ERLIN2 disrupt ERAD mechanisms, leading to protein aggregation and neuronal degeneration. Additionally, ERLIN2 antibodies aid in exploring its potential role in cancer, as altered expression has been observed in breast and prostate cancers. Research using these antibodies continues to uncover ERLIN2's broader implications in ER stress responses, lipid metabolism, and neurodegenerative diseases, highlighting its therapeutic and diagnostic potential.
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