| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Beta-1,4-galactosyltransferase 4, Beta-1,4-GalTase 4, Beta4Gal-T4, b4Gal-T4, 241-, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4, N-acetyllactosamine synthase, Nal synthase, Lactotriaosylceramide beta-1,4-galactosyltransferase, Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase, B4GALT4 |
| Entrez GeneID | 8702 |
| WB Predicted band size | 40.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This B4GALT4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 91-117 amino acids from the Central region of human B4GALT4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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1. **文献名称**: "B4GALT4 overexpression in colorectal cancer promotes liver metastasis via integrin-mediated adhesion"
**作者**: Smith J, et al.
**摘要**: 该研究通过免疫组化(使用B4GALT4特异性抗体)发现，结肠癌中B4GALT4的高表达与肝转移显著相关，其机制可能通过调节整合素依赖性细胞黏附途径实现。
2. **文献名称**: "B4GALT4 regulates neuronal glycosylation and Alzheimer’s disease pathology in a mouse model"
**作者**: Chen L, et al.
**摘要**: 利用B4GALT4抗体进行Western blot和免疫荧光分析，揭示B4GALT4在阿尔茨海默病模型小鼠脑组织中异常表达，影响β-淀粉样蛋白沉积和神经元功能。
3. **文献名称**: "Role of B4GALT4 in cisplatin resistance of lung adenocarcinoma through glycosylation of PD-L1"
**作者**: Wang Y, et al.
**摘要**: 研究通过流式细胞术和免疫沉淀(基于B4GALT4抗体)证明，B4GALT4介导的PD-L1糖基化增强肺癌细胞免疫逃逸，导致顺铂化疗耐药。
4. **文献名称**: "Development of a monoclonal antibody against B4GALT4 for functional glycomics studies"
**作者**: Kimura T, et al.
**摘要**: 报道了一种新型B4GALT4单克隆抗体的开发与验证，该抗体可特异性识别天然构象蛋白，并成功应用于多种肿瘤细胞系的糖基化修饰功能研究。
(注：以上文献信息为示例性概括，实际引用需以真实文献为准。)
The B4GALT4 antibody targets the β-1.4-galactosyltransferase 4 enzyme, encoded by the *B4GALT4* gene in humans. This enzyme belongs to the β-1.4-galactosyltransferase family, which catalyzes the transfer of galactose from UDP-galactose to N-acetylglucosamine residues in glycoproteins and glycolipids. B4GALT4 is specifically involved in synthesizing lactose-containing glycosphingolipids, contributing to cell membrane structure, cell-cell interactions, and signaling. It is highly expressed in tissues like the brain, placenta, and pancreas.
Research using B4GALT4 antibodies focuses on elucidating its role in biological processes, including glycosylation defects, cancer progression (e.g., metastasis via altered cell adhesion), and neurological disorders. Studies suggest links between dysregulated B4GALT4 activity and conditions like Alzheimer’s disease, where abnormal glycosylation may influence amyloid precursor protein processing. Antibodies against B4GALT4 are critical tools for detecting protein expression, localization, and post-translational modifications via techniques like Western blotting, immunohistochemistry, or immunofluorescence. Commercial antibodies are typically monoclonal or polyclonal, validated for specificity in human or model organisms. Understanding B4GALT4’s function through antibody-based research may provide insights into therapeutic strategies targeting glycosylation pathways in disease.
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