| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein 768, ZNF768 |
| Entrez GeneID | 79724 |
| WB Predicted band size | 60.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZNF768 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-29 amino acids from the N-terminal region of human ZNF768. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZNF768(N-term)抗体的假设性参考文献示例(注：实际文献可能需要通过PubMed或Google Scholar进一步检索确认)：
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1. **文献名称**: *"ZNF768 regulates transcriptional elongation through RNA polymerase II interaction"*
**作者**: Smith J, et al.
**摘要**: 本研究利用ZNF768(N-term)抗体进行免疫沉淀和ChIP-seq分析，发现ZNF768通过其N端结构域与RNA聚合酶II结合，调控基因转录延伸过程，影响细胞周期相关基因的表达。
2. **文献名称**: *"Characterization of ZNF768 subcellular localization in human cell lines"*
**作者**: Zhang L, et al.
**摘要**: 通过ZNF768(N-term)抗体的免疫荧光染色，作者证实ZNF768主要定位于细胞核，并在应激条件下(如DNA损伤)易位至核仁，提示其在核应激反应中的潜在作用。
3. **文献名称**: *"Proteomic screening identifies ZNF768 as a novel oncogenic driver in lung adenocarcinoma"*
**作者**: Lee H, et al.
**摘要**: 使用ZNF768(N-term)抗体进行Western blot和免疫组化分析，发现ZNF768在肺癌组织中高表达，且其表达水平与患者预后显著相关，功能实验表明其通过调控EGFR信号通路促进肿瘤生长。
4. **文献名称**: *"Validation of a polyclonal ZNF768 antibody for functional genomics studies"*
**作者**: Johnson R, et al.
**摘要**: 该研究系统验证了ZNF768(N-term)抗体的特异性，通过敲低/过表达实验证明抗体识别的信号强度与ZNF768蛋白水平一致，并提供了其在流式细胞术和免疫印迹中的优化条件。
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**注意**：以上内容为示例性回答，实际文献可能需要通过学术数据库检索。建议用户通过关键词“ZNF768 antibody”、“ZNF768 N-terminal”或相关研究领域结合抗体应用(如ChIP、IF等)进一步查询。
The ZNF768 (N-term) antibody is designed to target the N-terminal region of the zinc finger protein 768 (ZNF768), a less-characterized member of the zinc finger protein family. Zinc finger proteins are known for their roles in DNA binding, transcriptional regulation, and protein-protein interactions, often via conserved zinc finger domains. ZNF768 contains multiple C2H2-type zinc finger motifs, suggesting potential involvement in nucleic acid binding or chromatin remodeling. However, its precise biological functions and signaling pathways remain under investigation.
This antibody is commonly used in research to detect ZNF768 expression in various experimental models, including Western blotting, immunofluorescence, and immunohistochemistry. Its specificity for the N-terminal region helps distinguish ZNF768 from other zinc finger proteins, aiding in studies exploring its subcellular localization, tissue distribution, or interaction partners. Recent studies suggest ZNF768 may play roles in cell cycle regulation, stress responses, or viral defense mechanisms, though mechanistic details are sparse.
The development and validation of the ZNF768 (N-term) antibody typically involve immunogen-derived peptides corresponding to the N-terminal sequence, followed by affinity purification and rigorous testing in knockout or knockdown models to confirm target selectivity. Its utility contributes to ongoing efforts to unravel ZNF768's physiological and pathological relevance, particularly in cancer or autoimmune diseases where zinc finger proteins are frequently dysregulated.
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