| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Gamma-aminobutyric acid receptor-associated protein-like 3, GABA(A) receptor-associated protein-like 3, GABARAPL3 |
| WB Predicted band size | 14.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This GABARAPL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-53 amino acids from the Central region of human GABARAPL3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于GABARAPL3抗体的参考文献及其摘要概括：
1. **文献名称**：GABARAPL3 is essential for the autophagy-dependent secretion of von Willebrand factor
**作者**：Suzuki SW, et al.
**摘要**：该研究利用GABARAPL3特异性抗体，揭示其在血管内皮细胞中调控自噬依赖性分泌途径的作用，特别是对血管性血友病因子(vWF)的分泌机制。
2. **文献名称**：Characterization of GABARAPL3 as a novel regulator of autophagosome-lysosome fusion
**作者**：Liang C, et al.
**摘要**：通过免疫沉淀和免疫荧光技术结合GABARAPL3抗体，证明该蛋白通过与STX17复合物互作，促进自噬体-溶酶体融合，维持细胞稳态。
3. **文献名称**：GABARAPL3 modulates EGFR trafficking by bridging vesicle transport and autophagy
**作者**：Chen Y, et al.
**摘要**：研究使用GABARAPL3抗体进行蛋白质组学分析，发现其通过协调EGFR的内吞运输与自噬降解，影响肿瘤细胞增殖和迁移，为癌症治疗提供潜在靶点。
注：上述文献信息为模拟示例，实际文献需通过PubMed或Google Scholar检索确认。
The GABARAPL3 antibody is a tool used to detect GABARAPL3 (Gamma-aminobutyric acid receptor-associated protein-like 3), a member of the GABARAP family involved in intracellular membrane trafficking and autophagy. GABARAPL3. also termed as GATE-16 or ATG8L, shares structural homology with ubiquitin-fold proteins and plays roles in autophagosome formation, vesicle transport, and cargo recognition during autophagy. It interacts with microtubule-associated proteins and modulates membrane fusion events, particularly in neurotransmitter receptor trafficking (e.g., GABA receptors) and organelle biogenesis.
Research on GABARAPL3 is linked to studying autophagy-related disorders, cancer progression (where autophagy may promote tumor survival), and neurodegenerative diseases (e.g., Alzheimer’s). Antibodies targeting GABARAPL3 enable detection via techniques like Western blotting, immunofluorescence, or immunoprecipitation, aiding in elucidating its expression patterns and mechanistic roles. Commercial antibodies are typically validated for specificity against conserved epitopes, though cross-reactivity with homologous family members (e.g., GABARAP, GABARAPL1/2) requires careful evaluation. Studies using GABARAPL3 antibodies often focus on its subcellular localization, interaction networks, and regulatory pathways, contributing to therapeutic targeting of autophagy in disease contexts.
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