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Rabbit Polyclonal DHRS4L2 Antibody

  • 中文名: DHRS4L2抗体
  • 别    名: Dehydrogenase/reductase SDR family member 4-like 2, 11--, DHRS4L2
货号: IPDX31982
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesDehydrogenase/reductase SDR family member 4-like 2, 11--, DHRS4L2
WB Predicted band size24.9kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis DHRS4L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-158 amino acids from the Central region of human DHRS4L2.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于DHRS4L2抗体的3篇参考文献示例(注:部分文献信息为模拟概括,实际文献需通过数据库验证):

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### 1. **文献名称**: *DHRS4L2 promotes hepatocellular carcinoma progression by regulating retinoic acid signaling*

**作者**: Li X, Zhang Y, Chen W, et al.

**摘要**: 本研究探讨DHRS4L2在肝癌中的功能及机制。通过免疫组化(使用DHRS4L2特异性抗体)发现其在肝癌组织中高表达,并与患者预后不良相关。实验表明DHRS4L2通过抑制视黄酸代谢通路促进肿瘤细胞增殖和转移。

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### 2. **文献名称**: *Epigenetic regulation of DHRS4L2 in colorectal cancer and its interaction with the Wnt/β-catenin pathway*

**作者**: Wang H, Liu T, Zhou J.

**摘要**: 研究利用Western blot和免疫荧光技术(采用DHRS4L2抗体)分析结直肠癌中DHRS4L2的表达,发现其受DNA甲基化调控。DHRS4L2过表达激活Wnt通路,增强肿瘤侵袭性,提示其作为潜在治疗靶点。

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### 3. **文献名称**: *DHRS4L2 as a novel biomarker for cancer stem cells in breast cancer*

**作者**: Gupta S, Patel R, Kim A.

**摘要**: 通过流式细胞术和免疫沉淀(使用抗DHRS4L2抗体),研究发现DHRS4L2在乳腺癌干细胞中高表达,并参与维持干细胞特性。敲低DHRS4L2可减少肿瘤球形成,提示其与化疗耐药相关。

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**备注**:以上文献为示例,实际研究中请通过PubMed、Google Scholar等平台以关键词“DHRS4L2 antibody”或“DHRS4L2 function”检索最新论文,并注意结合具体实验场景(如癌症类型、分子机制)筛选文献。

背景信息

The DHRS4L2 antibody is a tool used to detect the dehydrogenase/reductase 4-like 2 (DHRS4L2) protein, a member of the short-chain dehydrogenase/reductase (SDR) superfamily. DHRS4L2 is a poorly characterized protein believed to play roles in cellular metabolism, steroidogenesis, or retinoid processing, though its exact biological functions remain unclear. It is part of a primate-specific gene cluster formed by tandem duplication, including DHRS4 and its pseudogenes, which complicates its study. Research suggests DHRS4L2 may act as a non-coding RNA regulator or participate in gene cluster co-regulation. The antibody is typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. It enables detection of DHRS4L2 expression in tissues or cell lines via techniques such as Western blotting, immunohistochemistry, or immunofluorescence. Specificity validation (e.g., knockout controls) is critical due to high homology within the DHRS4 gene family. Current studies focus on DHRS4L2's potential links to cancers, metabolic disorders, or neurological conditions, though its clinical relevance remains exploratory. This antibody supports ongoing efforts to clarify DHRS4L2's molecular interactions and pathophysiological significance.

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