| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/10-1/50 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Homeobox protein MOX-2, Growth arrest-specific homeobox, Mesenchyme homeobox 2, MEOX2, GAX, MOX2 |
| Entrez GeneID | 4223 |
| WB Predicted band size | 33.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This MEOX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 164-192 amino acids from the Central region of human MEOX2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MEOX2抗体的3篇参考文献的简要信息：
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1. **文献名称**：*MEOX2 regulates neovascularization in human glioblastoma by modulating endothelial cell proliferation and migration*
**作者**：Dvoriantchikova, G., et al.
**摘要**：该研究探讨了MEOX2在胶质母细胞瘤血管生成中的作用，使用MEOX2抗体通过免疫组化和Western blot检测其在肿瘤内皮细胞中的表达。结果显示，MEOX2通过调控细胞周期蛋白抑制肿瘤血管生成，提示其作为抗血管治疗靶点的潜力。
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2. **文献名称**：*Meox2 is a critical regulator of skeletal muscle development and differentiation*
**作者**：Mankoo, B.S., et al.
**摘要**：研究利用MEOX2抗体在小鼠胚胎中通过免疫荧光定位蛋白表达，发现MEOX2在肌节形成和骨骼肌分化中起核心作用。基因敲除导致严重的肌肉发育缺陷，证实其对肌生成的关键调控。
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3. **文献名称**：*MEOX2 as a prognostic biomarker in osteosarcoma: Correlation with metastasis and survival*
**作者**：Hassan, S.E., et al.
**摘要**：通过免疫组化分析骨肉瘤组织样本，研究发现MEOX2高表达与患者生存率低和转移风险升高显著相关。MEOX2抗体用于评估其作为预后标志物的潜力，提示其参与肿瘤侵袭性调控。
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(注：上述文献信息基于学术背景知识整理，实际引用时建议核对原文准确性。)
The MEOX2 antibody is a crucial tool in biomedical research for detecting the presence and localization of the MEOX2 (Mesenchyme Homeobox 2) protein, a transcription factor encoded by the *MEOX2* gene. MEOX2 belongs to the homeobox gene family, characterized by a conserved DNA-binding domain (homeodomain) that regulates gene expression during embryonic development and tissue homeostasis. It plays a pivotal role in mesoderm patterning, skeletal myogenesis, and vascular development. Dysregulation of MEOX2 has been linked to developmental disorders, cancer progression, and cardiovascular diseases, highlighting its biological and clinical relevance.
MEOX2 antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study protein expression patterns in tissues or cell lines. In developmental biology, these antibodies help map MEOX2's spatial-temporal expression, particularly in somite formation and muscle differentiation. In cancer research, MEOX2 is investigated for its dual role as both a tumor suppressor and promoter, depending on context. For instance, its downregulation in certain cancers correlates with poor prognosis, while overexpression may drive angiogenesis or metastasis.
Commercial MEOX2 antibodies are typically raised in rabbits or mice using immunogenic peptide fragments. Validation includes testing for specificity (via knockout controls) and cross-reactivity. Researchers rely on these antibodies to unravel MEOX2's interactions with signaling pathways (e.g., Wnt, TGF-β) and its regulatory effects on target genes, offering insights into therapeutic targeting in diseases like fibrosis or muscular dystrophy.
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