| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SH3 and cysteine-rich domain-containing protein, Src homology 3 and cysteine-rich domain-containing protein, STAC |
| Entrez GeneID | 6769 |
| WB Predicted band size | 44.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This STAC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 279-305 amino acids from the C-terminal region of human STAC. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3-4条关于STAC抗体的参考文献及其摘要内容的简要概括(注：文献标题和作者为模拟示例，具体文献需根据实际数据库检索)：
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1. **文献名称**: *"Development and Validation of a Monoclonal Antibody Targeting STAC3 for Neuromuscular Disease Research"*
**作者**: Smith A, et al.
**摘要**: 本研究开发了一种特异性识别STAC3蛋白的单克隆抗体，验证了其在免疫印迹(Western blot)和免疫荧光中的应用。该抗体成功用于检测STAC3在肌肉组织中的表达异常，为先天性肌病机制研究提供了工具。
2. **文献名称**: *"STAC1 Antibody Reveals Its Role in Neuronal Calcium Channel Trafficking"*
**作者**: Chen L, et al.
**摘要**: 通过高亲和力STAC1抗体，研究者发现STAC1通过与L型钙通道相互作用调控神经元钙信号传导，抗体阻断实验证实了其在突触可塑性和神经退行性疾病中的潜在作用。
3. **文献名称**: *"A Novel Polyclonal STAC2 Antibody for Detecting Cancer-Associated Isoforms"*
**作者**: Rodriguez M, et al.
**摘要**: 报道了一种针对STAC2多肽表位的多克隆抗体，能够特异性识别多种癌症中异常剪接的STAC2变体，并揭示了其在肿瘤迁移和化疗耐药中的功能。
4. **文献名称**: *"STAC Proteins as Biomarkers: Comparative Analysis of Antibody-Based Detection Methods"*
**作者**: Kim J, et al.
**摘要**: 对比了市售STAC家族(STAC1/2/3)抗体的灵敏度和特异性，提出了优化实验方案，为STAC蛋白在心血管疾病和代谢综合征中的生物标志物研究提供技术参考。
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如需具体文献，建议通过PubMed或Google Scholar检索关键词(如“STAC antibody”“STAC3 monoclonal”等)获取最新研究。
STAC (SH3 and cysteine-rich domain-containing) proteins are a family of adaptor molecules involved in cellular signaling and ion channel regulation. Discovered in the late 1990s, the three mammalian STAC isoforms (STAC1. STAC2. STAC3) share conserved domains: an N-terminal SH3 domain for protein interactions and cysteine-rich regions potentially influencing redox sensitivity. STAC proteins interact with key signaling components like voltage-gated calcium channels (Cav1.1) and the ryanodine receptor, modulating excitation-contraction coupling in skeletal muscle.
STAC3. the most studied isoform, is crucial for skeletal muscle function. Its mutation causes Native American myopathy, a congenital disorder characterized by muscle weakness. Antibodies targeting STAC proteins have become essential tools for elucidating their roles in physiological and pathological contexts. They enable detection of protein expression patterns, subcellular localization, and interaction partners through techniques like Western blotting, immunofluorescence, and co-immunoprecipitation. Recent studies also explore STAC's involvement in neurological disorders and cancer progression.
The development of specific STAC antibodies has accelerated research into muscle-related diseases and calcium signaling dysregulation, offering potential diagnostic and therapeutic insights. Their application continues to uncover novel regulatory mechanisms in cellular excitability and stress responses.
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