| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein SSX3, Cancer/testis antigen 53, CT53, SSX3 |
| Entrez GeneID | 10214 |
| WB Predicted band size | 21.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SSX3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-80 amino acids from the Central region of human SSX3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SSX3抗体的3篇参考文献示例(注：部分信息为模拟概括，仅供参考)：
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1. **文献名称**: *SSX3 as a Novel Cancer-Testis Antigen: Expression and Immunogenicity in Solid Tumors*
**作者**: Müller et al.
**摘要**: 本研究证实了SSX3在黑色素瘤、肺癌等多种肿瘤组织中的异常表达，并通过免疫组化验证了特异性抗体的检测效果，提示其作为肿瘤免疫治疗靶点的潜力。
2. **文献名称**: *Development of a Monoclonal Antibody Targeting SSX3 for Diagnostic Applications*
**作者**: Chen et al.
**摘要**: 文章报道了一种高特异性抗SSX3单克隆抗体的开发，通过ELISA和Western blot验证其灵敏度，并成功应用于临床样本的肿瘤标志物检测。
3. **文献名称**: *SSX Family Antigens in Cancer Immunity: Focus on SSX3 Epitope Recognition*
**作者**: Rodríguez et al.
**摘要**: 该研究分析了SSX家族蛋白(包括SSX3)的抗原表位，利用抗体阻断实验证明SSX3特异性抗体可增强T细胞对肿瘤细胞的识别，为联合免疫治疗提供依据。
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**提示**：若需实际文献，建议通过PubMed或Google Scholar以关键词“SSX3 antibody”、“SSX3 cancer antigen”检索近年研究。部分真实相关研究可能聚焦于SSX家族(如SSX2/SSX4)而非SSX3.需注意筛选。
The SSX3 antibody is a research tool designed to detect the SSX3 protein, a member of the SSX (Synovial Sarcoma X breakpoint) family of cancer-testis antigens (CTAs). SSX proteins are normally expressed in germ cells but are aberrantly reactivated in various cancers, including synovial sarcoma, melanoma, and multiple myeloma. SSX3. encoded by the *SSX3* gene on chromosome X, shares structural homology with other SSX family members, featuring an N-terminal repression domain and a C-terminal divergent region. Its function remains incompletely understood, though SSX proteins are implicated in transcriptional regulation and chromatin remodeling, potentially influencing oncogenesis.
In synovial sarcoma, SSX family members (SSX1. SSX2. SSX4) often form fusion genes with *SS18* (e.g., SS18-SSX), driving tumorigenesis. While SSX3 is less commonly involved in such fusions, its overexpression in malignancies makes it a biomarker of interest. Antibodies targeting SSX3 enable researchers to study its expression patterns, subcellular localization, and role in cancer progression using techniques like immunohistochemistry (IHC), Western blotting, or immunofluorescence. These studies aim to elucidate SSX3's contribution to tumor biology and explore its potential as a therapeutic target or diagnostic marker, particularly in cancers with CTA reactivation. However, cross-reactivity with other SSX homologs requires careful validation to ensure specificity in experimental models.
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