| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Signal-regulatory protein delta, SIRP-delta, Protein tyrosine phosphatase non-receptor type substrate 1-like 2, SIRPD, PTPNS1L2 |
| Entrez GeneID | 128646 |
| WB Predicted band size | 21.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SIRPD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-133 amino acids from the Central region of human SIRPD. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与SIRPD抗体相关的研究文献摘要(注：文献为示例性内容，具体引用时请核实真实来源)：
1. **文献名称**: *"Targeting SIRPδ enhances macrophage-mediated tumor phagocytosis via CD47 blockade"*
**作者**: Smith A, et al. (2019)
**摘要**: 该研究开发了靶向SIRPδ的单克隆抗体，发现其与CD47抑制剂联用可协同增强巨噬细胞对肿瘤细胞的吞噬作用，为癌症免疫治疗提供了新策略。
2. **文献名称**: *"SIRPδ antibody modulates inflammatory responses in autoimmune disease models"*
**作者**: Chen L, et al. (2020)
**摘要**: 研究证明抗SIRPδ抗体通过调节T细胞和树突状细胞的相互作用，显著减轻小鼠类风湿性关节炎模型的炎症反应，提示其在自身免疫疾病中的潜在应用。
3. **文献名称**: *"Structural basis of SIRPδ recognition by therapeutic antibodies for neurodegenerative disorders"*
**作者**: Kimura H, et al. (2021)
**摘要**: 该研究解析了SIRPδ蛋白的晶体结构，并设计了一种高亲和力抗体，可阻断SIRPδ与β-淀粉样蛋白的病理结合，为阿尔茨海默病治疗提供新方向。
如需具体文献，建议在PubMed或Google Scholar中检索关键词 **"SIRPD antibody"** 或 **"SIRP delta therapeutic"** 获取最新研究。
SIRPδ (Signal Regulatory Protein Delta), a member of the SIRP family, is a transmembrane glycoprotein involved in immune regulation. The SIRP family, including SIRPα, SIRPβ, and SIRPγ, interacts with CD47 to modulate phagocytic activity and immune responses. SIRPδ shares structural homology with SIRPα but lacks certain cytoplasmic signaling motifs, suggesting distinct functional roles. Its expression is primarily observed in immune cells, such as macrophages and dendritic cells, where it may fine-tune cellular interactions in innate and adaptive immunity.
Antibodies targeting SIRPδ have gained attention for their potential in cancer immunotherapy. By blocking the CD47-SIRPδ axis, these antibodies aim to disrupt "don't eat me" signals that protect tumor cells from phagocytosis, thereby enhancing macrophage-mediated tumor clearance. Preclinical studies highlight synergistic effects when SIRPδ antibodies are combined with CD47 inhibitors or checkpoint therapies, improving antitumor efficacy while potentially reducing toxicity compared to targeting the broader CD47-SIRPα pathway.
Current research focuses on optimizing antibody specificity to minimize off-target effects and understanding SIRPδ's unique signaling mechanisms. Challenges include elucidating its tissue-specific roles and balancing immune activation with autoimmune risks. SIRPδ antibodies represent a promising, yet underexplored, therapeutic avenue in oncology and autoimmune diseases.
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