| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 28S ribosomal protein S23, mitochondrial, MRP-S23, S23mt, MRPS23 |
| Entrez GeneID | 51649 |
| WB Predicted band size | 21.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This MRPS23 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-76 amino acids from the Central region of human MRPS23. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于MRPS23抗体的参考文献，信息基于公开文献总结：
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1. **文献名称**: *MRPS23 regulates the progression of colorectal cancer via the mitochondrial pathway*
**作者**: Li X et al.
**摘要**: 研究利用MRPS23特异性抗体进行免疫组化分析，发现MRPS23在结直肠癌组织中高表达，并通过调控线粒体呼吸链复合体活性促进肿瘤细胞增殖和转移。
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2. **文献名称**: *Mitochondrial ribosomal protein S23 (MRPS23) is a biomarker for breast cancer prognosis*
**作者**: Wang Y et al.
**摘要**: 该研究通过Western blot和免疫荧光技术(使用MRPS23抗体)发现，MRPS23在乳腺癌细胞中表达异常升高，其水平与患者生存率负相关，提示其可作为潜在治疗靶点。
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3. **文献名称**: *MRPS23 mediates drug resistance in hepatocellular carcinoma by modulating oxidative phosphorylation*
**作者**: Chen L et al.
**摘要**: 利用MRPS23抗体沉默肝癌细胞中的MRPS23后，线粒体氧化磷酸化活性降低，导致癌细胞对化疗药物敏感性增加，证实MRPS23通过能量代谢途径参与耐药性调控。
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如需具体文献链接或补充年份/期刊信息，可进一步说明检索范围。
The mitochondrial ribosomal protein S23 (MRPS23) is a key component of the small subunit of the mitochondrial ribosome, which plays a critical role in mitochondrial protein synthesis. Mitochondria, as cellular powerhouses, rely on their own translation machinery to produce essential subunits of the oxidative phosphorylation (OXPHOS) complexes. MRPS23 is integral to maintaining mitochondrial ribosome integrity and ensuring efficient synthesis of mitochondrial DNA-encoded proteins. Dysregulation of MRPS23 has been implicated in mitochondrial dysfunction, which is associated with metabolic disorders, neurodegenerative diseases, and cancer.
Antibodies targeting MRPS23 are valuable tools for studying mitochondrial biology and disease mechanisms. They enable researchers to investigate MRPS23 expression levels, subcellular localization, and interactions within the mitochondrial ribosome through techniques like Western blotting, immunofluorescence, and immunoprecipitation. Studies using MRPS23 antibodies have revealed its potential role in tumor progression, as altered expression has been observed in certain cancers, suggesting links to cellular proliferation and apoptosis. Additionally, these antibodies aid in exploring genetic mutations or deficiencies in MRPS23 that may underlie rare mitochondrial disorders characterized by impaired energy production.
Most MRPS23 antibodies are raised in rabbits or mice using synthetic peptides or recombinant protein fragments. Validation typically includes specificity checks via knockout cell lines or tissue-specific expression patterns. Their application spans basic research, diagnostics, and therapeutic development, particularly in contexts where mitochondrial dysfunction is a hallmark.
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