| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein 703, Zinc finger elbow-related proline domain protein 1, ZNF703, ZEPPO1, ZPO1 |
| Entrez GeneID | 80139 |
| WB Predicted band size | 58.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZNF703 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-254 amino acids from the Central region of human ZNF703. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是3篇关于ZNF703抗体的代表性文献(人工整理示例，实际文献请通过数据库验证)：
---
1. **文献名称**: *ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium*
**作者**: Holland DG et al.
**摘要**: 研究通过免疫组化(使用ZNF703抗体)发现ZNF703在Luminal B型乳腺癌中高表达，并证实其过表达可通过抑制分化促进肿瘤生长，提示其作为治疗靶点的潜力。
---
2. **文献名称**: *ZNF703 promotes tumor cell proliferation and invasion in ovarian cancer*
**作者**: Liu Y et al.
**摘要**: 利用ZNF703抗体进行Western blot和免疫荧光实验，证明ZNF703在卵巢癌中通过激活Wnt/β-catenin信号通路促进肿瘤侵袭，沉默ZNF可抑制癌细胞增殖。
---
3. **文献名称**: *Amplification and overexpression of ZNF703 in breast cancer genomes*
**作者**: Reynisdottir S et al.
**摘要**: 通过FISH和免疫组化(ZNF703抗体)分析，揭示ZNF703基因在乳腺癌中频繁扩增，其过表达与患者预后不良相关，提示可作为分子分型标志物。
---
**注**：以上为模拟示例，实际文献需通过PubMed(PMID: 21558571. 25569146等)或学术数据库检索确认。
The ZNF703 antibody is a crucial tool for studying the zinc finger protein 703 (ZNF703), a member of the NET/NlZ family of transcriptional regulators. ZNF703. located on chromosome 8p11. has gained attention for its role in cancer biology, particularly in luminal breast cancer. It functions as an oncogenic driver, promoting cell proliferation, survival, and tumorigenesis by modulating transcriptional programs. Studies suggest ZNF703 may act as a transcriptional repressor or co-activator, depending on cellular context, and interacts with signaling pathways like Notch and ERK to influence cancer progression. Amplification of the 8p11-12 genomic region, leading to ZNF703 overexpression, is linked to aggressive tumor behavior, therapy resistance, and poor prognosis.
The ZNF703 antibody enables detection and quantification of ZNF703 protein expression in experimental models and clinical samples. It is widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence to investigate ZNF703's subcellular localization, expression patterns in tumors, and associations with molecular subtypes. Researchers also employ it to explore ZNF703's role in maintaining cancer stem cell populations and epithelial-mesenchymal transition (EMT). Validated antibodies are essential for distinguishing ZNF703 from homologous family members (e.g., ZNF503), ensuring specificity in functional studies. As ZNF703 emerges as a potential therapeutic target, its antibody remains vital for elucidating oncogenic mechanisms and biomarker development.
×
