| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Coiled-coil domain-containing protein 151, CCDC151 |
| Entrez GeneID | 115948 |
| WB Predicted band size | 69.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CCDC151 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-46 amino acids from the N-terminal region of human CCDC151. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CCDC151 (N-term)抗体的示例参考文献(注：以下信息为示例性内容，实际文献可能存在差异，请结合具体数据库核实)：
1. **"CCDC151 is required for the assembly of motile cilia through interaction with microtubule-binding proteins"**
*作者：Lechtreck KF, et al. (2015)*
摘要：本研究利用N端特异性抗体证实CCDC151在纤毛基体中的定位，发现其与微管结合蛋白的相互作用对纤毛运动功能至关重要。
2. **"A homozygous mutation in CCDC151 causes male infertility due to sperm flagellum defects"**
*作者：Sironen A, et al. (2016)*
摘要：通过Western blot和免疫荧光(使用CCDC151 N-term抗体)发现，CCDC151基因突变导致精子尾部结构异常，证实其在鞭毛组装中的作用。
3. **"Antibody-based profiling of ciliary proteins reveals CCDC151 as a biomarker for primary ciliary dyskinesia"**
*作者：Omran H, et al. (2018)*
摘要：开发并验证了针对CCDC151 N端的多克隆抗体，用于诊断纤毛运动障碍患者中该蛋白的表达缺失或异常。
4. **"Validation of a novel CCDC151 antibody for immunofluorescence applications in ciliated cell models"**
*作者：Smith JL, et al. (2020)*
摘要：系统评估了CCDC151 (N-term)抗体在多种细胞系中的特异性，证明其在纤毛发生研究中的高灵敏度和可重复性。
**注意**：以上文献标题和内容为模拟生成，具体研究需通过PubMed或SciFinder等平台核实。建议使用关键词“CCDC151 antibody N-terminal”或“CCDC151 function”进行精确检索。
The CCDC151 (N-term) antibody is designed to target the N-terminal region of the coiled-coil domain-containing protein 151 (CCDC151), a critical component in the assembly and function of motile cilia and flagella. CCDC151 is highly conserved and primarily expressed in tissues with motile cilia, such as the respiratory epithelium, brain ependyma, and sperm flagella. It interacts with dynein axonemal intermediate chain 2 (DNAI2) to facilitate the proper docking of dynein arms to the ciliary microtubule structure, which is essential for ciliary movement and fluid propulsion.
Mutations in the CCDC151 gene are linked to primary ciliary dyskinesia (PCD), a genetic disorder characterized by impaired mucociliary clearance, chronic respiratory infections, and infertility. The N-terminal domain of CCDC151 is crucial for its interaction with DNAI2. making antibodies against this region valuable tools for studying ciliary ultrastructure defects and molecular mechanisms underlying PCD.
The CCDC151 (N-term) antibody is commonly used in immunofluorescence, Western blotting, and immunohistochemistry to visualize protein localization in ciliated tissues or cell models. It aids in diagnosing ciliary dysfunction and evaluating gene-editing or therapeutic interventions in preclinical research. Developed in host species like rabbit or mouse, it demonstrates specificity for human and model organism (e.g., mouse) CCDC151. supporting translational studies in respiratory and reproductive biology.
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